利培酮的电化学行为及应用研究

采用循环伏安法、线性扫描伏安法、常规脉冲伏安法和恒电位电解法等电化学手段, 详细研究了利培酮在pH 7.07～10.32 B-R缓冲溶液和0.2 mol?L^－1 NaOH溶液中的电化学行为. 研究表明: 在pH 7.07～10.07 B-R缓冲溶液中, 利培酮产生的P₁波为催化氢波. 在pH＝10.32 B-R缓冲溶液中, 利培酮可以产生P₂和P₃两个波. 其中, P₂波为不可逆的单电子还原波, P₃波可以分裂成两个波P_3a和P_3b. P_3a波为P₂波的进一步单电子还原, 而P_3b波则属于催化氢波. 在0.2 mol?L^－1 NaOH溶液中, 利培酮产生的P₄波是一个两电子的不可逆还原波. 另外, 根据P₁波的一阶导数峰电流与利培酮浓度在1.6×10^－5～2.0×10^－6 mol?L^－1 (r＝0.9950)间的线性关系, 建立了利培酮片剂中利培酮含量的测定新方法. 新方法的检出限为1.0×10^－6 mol?L^－1, 回收率在105%～102%之间, 相对标准偏差为0.84%.

Investigation on Electrochemical Behavior of Risperidone and Its Application

The electrochemical behavior of risperidone was studied in pH 7.07～10.32 B-R buffer solutions and 0.2 mol?L^－1 NaOH solution by means of cyclic voltammetry, linear sweep voltammetry, normal pulse voltammetry and controlled-potential electrolysis. Risperidone yielded one wave P₁ as pH of B-R buffer solution was changed from 7.07 up to 10.07, which was a catalytic hydrogen wave. Additional two waves P₂ and P₃ were exhibited in pH＝10.32 B-R buffer solution. P₂ wave was an irreversible adsorption reduction wave involving one electron. P₃ could be split into P_3a and P_3b. Of them, P_3a was the further reduction wave of P₂, and P_3b was a catalytic hydrogen wave. Otherwise, based on the linear relation between the first-order derivative peak current of P₁ and the concentration of risperidone in the range of 1.6×10^－5～2.0×10^－6 mol?L^－1 with a 0.995 correlation coefficient, a new method for determination of risperidone in risperidone tablets was described. The detection limit was 1.0×10^－6 mol?L^－1, and the recovery of risperidone was between 105% and 102% with a relative standard deviation of 0.84%.