| 尿中性粒细胞明胶酶相关脂质运载蛋白和血清胱抑素C在糖尿病肾病中的诊断价值 |
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| 引用本文： | 焦路阳,郭庆合,宋志善,鲁广建.尿中性粒细胞明胶酶相关脂质运载蛋白和血清胱抑素C在糖尿病肾病中的诊断价值[J].新乡医学院学报,2011,28(5):594-595,599. |
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| 作者姓名： | 焦路阳 郭庆合 宋志善 鲁广建 |
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| 作者单位： | 1. 新乡医学院第一附属医院检验科,河南 卫辉,453100
2. 新乡医学院医学检验系,河南 新乡,453003 |
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| 摘 要： | 目的探讨2型糖尿病(T2DM)患者尿中性粒细胞明胶酶相关脂质运载蛋白(NGAL)和血清胱抑素C(CYS-C)的改变及其对糖尿病肾病(DN)的诊断价值。方法选择T2DM患者70例,根据尿清蛋白排泄率(UAER)分为正常清蛋白尿组20例、微量清蛋白尿组25例和临床肾病组25例,并选取同期20例非肾病健康体检者作为对照组。应用酶联免疫吸附试验(ELISA)检测患者尿NGAL水平,应用免疫速率散射比浊法检测血清CYS-C水平,分析尿NGAL及血清CYS-C水平与肾小球滤过率(GFR)之间的关系。结果正常清蛋白尿组的尿NGAL较对照组明显升高,差别有统计学意义(P<0.05)。微量清蛋白尿组和临床肾病组的GFR、尿NGAL、血清CYS-C与对照组比较差别均有统计学意义(P<0.01)。临床肾病组的GFR、尿NGAL、血清CYS-C与微量清蛋白尿组比较差别有统计学意义(P<0.01)。糖尿病患者尿NGAL和血清CYS-C水平与GFR均呈负相关(r1=-0.312,r2=-0.412,P<0.05)。结论 T2DM患者尿NGAL与GFR有较好的相关性,测定尿NGAL和血清CYS-C可为早期诊断DN提供参考依据。
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| 关 键 词： | 中性粒细胞明胶酶相关脂质运载蛋白 血清胱抑素C 糖尿病肾病 |
Diagnostic value of urinary neutrophil gelatinase associated lipocalin and serum cystatin C on diabetic nephrathy |
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| JIAO Lu-yang,GUO Qing-he,SONG Zhi-shan,LU Guang-jian.Diagnostic value of urinary neutrophil gelatinase associated lipocalin and serum cystatin C on diabetic nephrathy[J].Journal of Xinxiang Medical College,2011,28(5):594-595,599. |
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| Authors: | JIAO Lu-yang GUO Qing-he SONG Zhi-shan LU Guang-jian |
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| Affiliation: | JIAO Lu-yang1,GUO Qing-he2,SONG Zhi-shan2,LU Guang-jian1 (1.Department of Clinical Laboratory,the First Affiliated Hospital of Xinxiang Medical College,Weihui 453100,Henan Province,China,2.Department of Laboratory Medicine,Xinxiang Medical College,Xingxiang 453003,China) |
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| Abstract: | Objective To explore the changes of urinary neutrophil gelatinase associated lipocalin(NGAL) and serum cystatin C(CYS-C) in type 2 diabetes mellitus(T2DM)patients,and their diagnostic value on diabetic nephrathy(DN). Methods Seventy cases with T2DM were selected.The patients were divided into 3 groups according to the urinary albumin excretion rate(UAER),which includes normal albuminuria group(n=20),micro-albuminuria group(n=25) and clinical nephrosis group(n=25).Twenty healthy people without nephrosis were... |
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| Keywords: | neutrophil gelatinase-associated lipocalin cystatin C diabetic nephropathy |
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