甲状腺疾病孕妇尿碘、SOD与甲状腺激素的关系及对妊娠结局的影响

目的研究甲状腺疾病孕妇尿碘、超氧化物歧化酶及甲状腺激素的关系,探讨甲状腺疾病与氧化应激的关系,为预防甲状腺疾病孕妇不良妊娠提供依据。方法随机选取佛山市禅城区中心医院门诊产检孕妇450例,其中疾病组300例、对照组150例,分别抽取静脉血5mL并随机收集1次晨尿。采用电化学发光法检测甲状腺激素及甲状腺自身抗体,采用碘催化砷铈反应原理检测尿碘,采用邻苯三酚自氧化法检测超氧化物歧化酶活力。结果对照组超氧化物歧化酶水平显著高于疾病组,差异有统计学意义(P0.05);碘充足组超氧化物歧化酶水平显著高于碘异常组,差异有统计学意义(P0.05);甲状腺疾病孕妇不良妊娠结局显著高于对照组,差异有统计学意义(P0.05)。结论甲状腺疾病孕妇尿碘、超氧化物歧化酶及甲状腺激素间具有密切关系,及时处理甲状腺疾病与氧化应激反应,对预防甲状腺疾病孕妇不良妊娠的发生具有重要意义。

Correlation among urinary iodine,SOD and thyroid hormone in pregnant women with thyroid diseases and their influence on pregnant outcome

Objective To investigate the relations among urinary iodine level ,superoxide dismutase(SOD) activity and thyroid hormone levels in pregnant women with thyroid diseases and to explore the relation between thyroid diseases and oxidative stress so as to provide a basis for preventing adverse pregnancy outcome in pregnant women with thyroid diseases .Methods A total of 450 pregnant women undergoing the outpatient antenatal check‐up in our hospital were randomly chosen ,including 300 cases in the dis‐ease group and 150 cases in the control group .Five mL of venous blood and once next morning urine sample were collected from each case .The levels of thyroid hormones and thyroid autoantibodies were determined by using the electrochemiluminescence meth‐od .The urinary iodine concentration was measured by adopting the iodine catalyed As‐Ce reaction principle .The SOD activity was determined by using the pyrogallol autoxidation method .Results The SOD level of the control group was significantly higher that of the disease group ,the difference was statistically significant (P<0 .05);the SOD level in the iodine replete group was significant‐ly higher than that in the iodine group ,the difference was statistically significant (P<0 .05);the adverse pregnancy outcome in the thyroid disease pregnant women was than that in the control group with statistical difference (P<0 .05) .Conclusion The urinary i‐odine level ,SOD activity and thyroid hormone levels in pregnant women with thyroid diseases have close relation .Timely treating thyroid diseases and oxidative stress reaction has an important significance in preventing the occurrence of adverse pregnancy out‐come in pregnant women with thyroid diseases .