| 免疫抑制剂FTY720及其类似物 |
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| 引用本文： | 恽亚军,徐云根.免疫抑制剂FTY720及其类似物[J].药学进展,2008,32(7):309-313. |
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| 作者姓名： | 恽亚军 徐云根 |
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| 作者单位： | 中国药科大学新药研究中心,江苏,南京,210009 |
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| 摘 要： | 神经鞘氨醇类似物FTY720是一种新型的免疫抑制剂，可用于器官移植的抗排斥反应以及自身免疫性疾病、肿瘤和炎症等的治疗，目前在肾移植排斥反应的治疗方面已进入Ⅲ期临床试验，在多发性硬化症的治疗方面已进入Ⅱ期临床试验。综述FTY720及其类似物的研究进展。
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| 关 键 词： | FTY720 免疫抑制剂 鞘氨醇 |
A Review of Immunosuppressant FTY720 and its Analogs |
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| YUN Ya-jun,XU Yun-gen.A Review of Immunosuppressant FTY720 and its Analogs[J].Progress in Pharmaceutical Sciences,2008,32(7):309-313. |
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| Authors: | YUN Ya-jun XU Yun-gen |
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| Affiliation: | (Center of Drug Discovery, China Pharmaceutical University, Nanjing 210009, China) |
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| Abstract: | FTY720, 2-amino-2-2-（4-octylphenyl） ethyl] propane-1, 3-diol hydrochloride, is an oral sphingosine-1-phosphate receptor agonist and immunosuppressant being developed for anti-rejection in organ transplantation, autoimmune disorders, tumor and inflammatory diseases. Phase Ⅲ clinical trial of FTY720 in the treatment of graft rejection episodes after renal transplantation and phase Ⅱ clinical trial in the treatment of multiple sclerosis are underway. The recent developments of FTY720 and its analogs were reviewed. |
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| Keywords: | FTY720 Immunosuppressant Sphingosine |
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