| 电子直线加速器照射对NIH 3T3细胞的细胞周期及凋亡的影响 |
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| 引用本文： | 徐岚,周迎会,史宁,彭淼,吴士良.电子直线加速器照射对NIH 3T3细胞的细胞周期及凋亡的影响[J].苏州大学学报(自然科学版),2002,22(2):130-132. |
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| 作者姓名： | 徐岚 周迎会 史宁 彭淼 吴士良 |
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| 作者单位： | 苏州大学生物化学与分子生物学教研室,苏州25007 |
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| 基金项目： | 国防科工委国防预研课题 (编号Y6 92 0 0 2 6 -0 4) |
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| 摘 要： | 目的 探讨电子直线加速器照射对细胞周期及细胞凋亡的影响。方法 采用直线加速器对NIH 3T3细胞进行照射，观察细胞周期及细胞凋亡的改变情况；同时测定损伤前后p53蛋白的表达情况。结果 照射后细胞凋亡数增加，p53蛋白表达量上升。结论 电子直线加速器照射损伤可诱导细胞凋亡。
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| 关 键 词： | 电子直线加速器 放射损伤 细胞凋亡 NIH3T3细胞 肿瘤 放射疗法 |
| 文章编号： | 1000-5749(2002)02-0130-03 |
| 修稿时间： | 2001年12月10 |
Study of Cell Cycle and Apoptosis after Radiation with Electron Linear Accelerator Injury |
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| XU Lan,ZHOU Ying-hui,SHI Ning,et al.Study of Cell Cycle and Apoptosis after Radiation with Electron Linear Accelerator Injury[J].Suzhou University Journal of Medical Science,2002,22(2):130-132. |
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| Authors: | XU Lan ZHOU Ying-hui SHI Ning |
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| Abstract: | Purpose To determine the cell cycle and apoptosis of the injuried cells after radiation with the electron linear accelerator.Methods NIH 3T3 cells were irradiated by the radiation with the electron linear accelerator. In the experiment the condition of the cell cycle and apoptosis of the injuried cells were measured. The expression of p53 was also tested. Results After exposure to radiation, the number of apoptotic cells as well as the expression of p53 increased.Conclusion The electron linear accelerator radiation injury can induce cell apoptosis. |
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| Keywords: | electron linear accelerator radiation injury apoptosis |
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