Short communication: Activity of nisin,lipid bilayer fragments and cationic nisin-lipid nanoparticles against multidrug-resistant Staphylococcus spp. isolated from bovine mastitis |
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| Authors: | L Castelani JRP Arcaro JEP Braga AS Bosso Q Moura F Esposito IP Sauter M Cortez N Lincopan |
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| Affiliation: | 1. Institute of Animal Science, Dairy Cattle Center, Nova Odessa, São Paulo, Brazil 13380-011;2. Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil 05508-900;3. Department of Clinical Analysis, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil 05508-900;4. Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil 05508-900 |
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| Abstract: | Staphylococci are the main etiological agents of bovine mastitis. Bacteriocins and nanoparticles have emerged as promising alternatives for the future development of antimicrobial agents. This study evaluated the activity of the bacteriocin nisin and bicelles of the synthetic cationic lipid dioctadecyldimethylammonium bromide, alone and in combination, against multidrug-resistant Staphylococcus spp. strains isolated from bovine mastitis. In summary, cationic nisin/dioctadecyldimethylammonium bromide nanoparticles are shown to be a promising alternative for the control of mastitis caused by multidrug-resistant Staphylococcus spp. |
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| Keywords: | bacteriocin cationic lipid bicelle antibacterial activity |
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