| HPLC-MS/MS法测花旗松素在Beagle犬血浆中的浓度及其药代动力学研究 |
| |
| 引用本文： | 仝瑶瑶,王文艳,张林琪,刘万卉.HPLC-MS/MS法测花旗松素在Beagle犬血浆中的浓度及其药代动力学研究[J].质谱学报,2009,30(Z1):116-117. |
| |
| 作者姓名： | 仝瑶瑶 王文艳 张林琪 刘万卉 |
| |
| 作者单位： | 烟台大学药学院，山东 烟台 264005 |
| |
| 摘 要： |
|
Determination of Taxifolin in Beagle Dogs Plasma by HPLC-MS/MS and Pharmacokinetic Study |
| |
| TONGYao-yao,WANGWen-yan,ZHANGLin-qi,LIUWan-hui.Determination of Taxifolin in Beagle Dogs Plasma by HPLC-MS/MS and Pharmacokinetic Study[J].Journal of Chinese Mass Spectrometry Society,2009,30(Z1):116-117. |
| |
| Authors: | TONGYao-yao WANGWen-yan ZHANGLin-qi LIUWan-hui |
| |
| Affiliation: | Phamaceutical School, Yantai university, Yantai 264005, China |
| |
| Abstract: | A rapid, sensitive and selective method for the determination of taxifolin in Beagle dog plasma was described by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). Resveratrol was used as internal standard (I.S.). MS detection and quantitation were done by mass spectrometer using selected reaction monitoring at m/z 303 and 285 M－H]－ for taxifolin, and m/z 227 and 185 M－H]－ for resveratrol. The calibration curve is linear (r＞0.998) from 2 to 1 000 μg L－1, and the lower limit of quantification(LLOQ) is 2 μg L－1. |
| |
| Keywords: | taxifolin HPLC-MS/MS pharmacokinetics |
|
| 点击此处可从《质谱学报》浏览原始摘要信息 |
|
点击此处可从《质谱学报》下载全文 |
|
