预混胰岛素治疗的2型糖尿病患者转为甘精胰岛素联合口服药治疗的疗效分析

目评价甘精胰岛素联合口服降糖药物(OADs)治疗方案对使用预混胰岛素血糖控制欠佳的2型糖尿病患者的疗效及安全性.方法 预混胰岛素30/70单独或联合使用OADs血糖控制不良的2型糖尿病患者50例,随机分为治疗组(停用预混胰岛素,改为皮下注射甘精胰岛素联合OADs,n=30)和对照组(继续使用预混胰岛素早、晚餐前皮下注射...

Analysis of efficacy of the treatment of insulin glargine combined with oral hypoglycemic drugs for type 2 diabetic patients using premixed insulin therapy

Objective To evaluate the efficacy and safety of the treatment of insulin glargine combined with oral hypoglycemic drugs (OADs) for type 2 diabetic patients with poor glycemic control using premixed insulin therapy.Methods Fifty cases of poor blood glucose control patients with type 2 diabetes using 30/70 premixed insulin alone or in combination with OADs were randomly divided into treatment group ( converting premixed insulin into insulin glargine plus OADs,n =30) and control group ( continue to use the premixed insulin plus OADs,n =20).All groups were adjusted the dosage of insulin and OADs based on the levels of blood glucose.After 12 weeks,monitoring and comparing fasting blood glucose(FBG),2 hour postprandial blood glucose(2 h PG),glycosylated hemoglobin A1c(HbA1c) levels,body mass index(BMI) and the incidence of hypoglycemia during the test of the two groups.Results Compared with those before treatment,HbA 1 c,FBG,2 h PG of both groups have declined ( all P ＜ 0.01 ).The treatment group and control group have no significant change in BMI (P ＞ 0.05 ).Compared with the control group,FBG,lunch 2 h PG,BMI and HbAlc of the treatment group is lower ( all P ＜0.01 ).The incidence of hypoglycemia during the test of the treatment group is lower( P ＜ 0.01 ).Conclusions The treatment of insulin glargine combined with OADs for poor glycemic control in type 2 diabetic patients using premixed insulin,can significantly improve the levels of FBG and HbA 1 c,do not increase body weight,and it is simple to use,therefore can significantly reduce the risk of hypoglycemia.