| 极重度骨髓型与肠型急性放射病的救治进展 |
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| 引用本文： | 胡锴勋,艾辉胜.极重度骨髓型与肠型急性放射病的救治进展[J].国际放射医学核医学杂志,2006,30(1):56-59. |
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| 作者姓名： | 胡锴勋 艾辉胜 |
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| 作者单位： | 100071,北京,解放军307医院血液科;100071,北京,解放军307医院血液科 |
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| 基金项目： | 国家“863”计划资助项目(2002AA216081) |
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| 摘 要： | 极重度骨髓型与肠型急性放射病(ARS)一直是医学难以攻克的热点问题。本文从4个方面概括ARS治疗的新进展:①WR-2721作为细胞防护剂的机制和早期应用,可能阻断组织器官的不可逆性放射损伤;②细胞因子治疗放射病的新进展,提出重视造血恢复后患者的免疫重建;③造血干细胞移植的适应证,骨髓间充质干细胞对放射病有重要治疗意义;④放射病的抗感染防护和治疗,临床真菌感染症状出现前,抗真菌用药的适应证。
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| 关 键 词： | 辐射防护剂 细胞因子类 造血干细胞 急性放射病 |
| 文章编号： | 1673-4114(2006)01-0056-04 |
| 收稿时间： | 2005-06-06 |
| 修稿时间： | 2005年6月6日 |
The progress in treatment of severe hematopoietic and intestinal form of acute radiation syndrome |
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| HU Kai-xun,AI Hui-sheng.The progress in treatment of severe hematopoietic and intestinal form of acute radiation syndrome[J].International Journal of Radiation Medicine and Nuclear Medicine,2006,30(1):56-59. |
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| Authors: | HU Kai-xun AI Hui-sheng |
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| Affiliation: | Department of Hematology, Affiliated Hospital of Academy of Military Medicine Science, Beijing 100071, China |
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| Abstract: | The acute radiation syndrome (ARS) is hard to be, overcome as the hot medical problem. This article presents the recent advances in the treatment: (1) The amifostin( WR-2721) be mechanism and earlier periods of the cell protection to apply may interrupt organize harm. ( 2 ) New directions for therapy are stressed, using cytokines to enhance recovery of hematopoiesis and immune reconstitution. (3) The article presents guidelines for the use of hematopoietic stem cell transplantation and the mesenchymal stem cells (MSCs ) have the importance treatment meaning to the ARS. (4) Indications of preemptive therapy of fungal infection in patients are described. |
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| Keywords: | Radioprotective drug Cytokine Hematopoietic stem cell Acute radiation syndrome |
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