| 人工合成白细胞介素-1受体阻断剂对大鼠葡萄膜炎的影响 |
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| 引用本文： | Zhou Y,Li Z,An W,Chiou G. 人工合成白细胞介素-1受体阻断剂对大鼠葡萄膜炎的影响[J]. 中华眼科杂志, 2000, 36(1): 62-64 |
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| 作者姓名： | Zhou Y Li Z An W Chiou G |
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| 作者单位： | |
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| 摘 要： | 目的 观察人工合成的白细胞介素－１受体阻断剂对大鼠葡萄膜炎的治疗作用。方法 选择１８只（３６只眼）Ｓｐｒａｇｕｅ＝Ｄａｗｌｅｙ大鼠,采用酶联免疫吸附测定的方法,对人工合成的ＩＬ－１受体阻断剂治疗前、后的大鼠葡萄膜炎动物模型的视网膜内ＩＬ－β和肿瘤坏死因子的含量进行测定。结果 ＩＬ－１受体阻断剂（ＣＫ－１３８,ＣＫ－１３９）治疗组,基 膜内ＩＬ－１β和ＴＮＦα的含量均显著低于对照组的含量。结论 人工
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| 关 键 词： | 葡萄膜炎 白细胞介素－1 肿瘤坏死因子 治疗 |
| 修稿时间： | 1999-05-04 |
Effects of synthetic interleukin-1 blockers on uveitis in rats |
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| Zhou Y,Li Z,An W,Chiou G. Effects of synthetic interleukin-1 blockers on uveitis in rats[J]. Chinese Journal of Ophthalmology, 2000, 36(1): 62-64 |
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| Authors: | Zhou Y Li Z An W Chiou G |
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| Affiliation: | Department of Ophthalmology, Tong Ren Hospital, The Capital University of Medical Sciences, Beijing 100730, China. |
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| Abstract: | OBJECTIVE: To investigate the therapeutic action of synthetic interleukin-1 blockers on uveitis in rats. METHOD: Experiments were performed on 18 Spraque-Dawley rats (36 eyes), and the retinal interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) were quantified by an enzyme-linked immunoabsorbent assay (ELISA) before and after the rats with uveitis treated by synthetic interleukin-1 blockers. RESULT: The retinal IL-1 beta and TNF-alpha in rats with uveitis treated by synthetic IL-1 blockers (CK-138, 139) were significantly decreased than those treated by contrasting design. CONCLUSION: Synthetic IL-1 blockers (CK-138, 139) are effective in treatment of IL-1 alpha induced uveitis in the rat. |
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| Keywords: | Uveitis Interleukin 1 Tumor necrosis factor |
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