Expression of BCL-2 oncoprotein on tumor cells and tumor-infiltrating lymphocytes (TIL) in meningiomas |
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Authors: | K Roessler W Dietrich K Kitz |
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Affiliation: | (1) Department of Neurosurgery, University Hospital of Vienna, Waehringer Guertel 18–20, A-1090 Vienna, Austria e-mail: karl.roessler@telecom.at Tel.: +43-1-40400-2566, Fax: +43-1-40400-4566, AT;(2) Cytological Laboratory and Department of Neurosurgery, University of Vienna Medical School, Vienna, Austria, AT |
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Abstract: | The Expression of the antiapoptotic oncoprotein BCL-2 and its correlation to tumor grade in 62 meningiomas (48 classic, 9
atypical, and 5 anaplastic) using single and double immunohistochemistry was investigated. BCL-2 expression was found in two
different cell populations identified as lymphocytes (BCL-2+CD3+) and tumor cells (BCL+/CD3–). Tumor-infiltrating lymphocytes
(TIL) (CD3+) were found within classic (9.5% of cells), atypical (2.4% of cells), and anaplastic (1.8% of cells) meningiomas.
In classic meningiomas, 66.5% of TIL were BCL-2-positive, in atypical meningiomas 79.2%, and in anaplastic meningiomas 37.9%.
In 33 (68.8%) of the classic meningiomas, medium to high counts of BCL-2+ tumor cells were detected. Atypical meningiomas
showed nearly equal percentages of high (two patients), medium (five patients), and low (two patients) BCL-2+ tumor cell counts,
whereas anaplastic meningiomas showed only medium (two patients) and low (three patients) BCL-2 tumor cell counts or were
BCL-2-negative (one patient). In summary, a significant inverse correlation between the number of BCL-2-positive tumor cells
and tumor grade in meningiomas was found. These findings support the hypothesis of cell survival prolongation by the antiapoptotic
ability of BCL-2 proto- oncogenes and demonstrate the prognostic relevance of BCL-2 immunoreactivity in meningiomas.
Received: 10 June 1998 / Accepted: 23 February 1999 |
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Keywords: | BCL-2 oncoprotein Ki67 index Meningiomas Tumor-infiltrating lymphocytes (TIL) |
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