酸枣仁安神酒中酸枣仁皂苷改善小鼠睡眠作用的研究

研究酸枣仁皂苷对改善小鼠睡眠作用的影响。分别以酸枣仁安神酒大小不同剂量组、酸枣仁水煎液组以及褪黑素阳性对照组、蒸馏水阴性对照组给小鼠连续灌胃12 d后,通过对小鼠自主活动影响实验、直接睡眠实验、延长戊巴比妥钠睡眠时间实验、戊巴比妥钠阈下剂量催眠实验,观察各组对小鼠睡眠的影响。与空白对照组比较酸枣仁安神酒、酸枣仁水溶液对小鼠的自主活动均有明显的抑制作用,能明显延长戊巴比妥钠诱导睡眠时间,均能明显增加阈下剂量戊巴比妥钠的小鼠入睡率,且无直接睡眠作用,对小鼠体重无明显影响。酸枣仁皂苷具有镇静催眠作用。

Study on the effect of Semen Ziziphi Spinosae sedative wine Jujuboside on sleep improvement of mice

To study the effect of jujuboside on the sleep of mice.Different doses of Semen Ziziphi Spinosae sedative wine,Semen Ziziphi Spinosae decoction,melatonin positive control group and water negative group was consecutively orally given to mice for 12 days.By measuring the spontaneous activity experiment of mice,the experiments of induced-sleep directly,prolonging sleeping time induced by pentobarbital sodium,affecting mouse sleeping rate under zhe threshold hypnogenesis dosage of pentobarbital sodium.The effec...