益气通脉饮联合西药治疗气虚血瘀型冠心病心绞痛90例临床疗效观察

目的:探讨益气通脉饮治疗气虚血瘀型冠心病心绞痛的临床疗效。方法:选取2017年10月—2019年2月烟台业达医院收治的气虚血瘀型冠心病心绞痛的患者90例作为研究对象,根据随机数字表法将所选患者均分为两组,每组各45例,两组的一般资料经统计学方法,差异无统计学意义(P>0.05),因此具有可比性。对照组给予常规西药进行治疗,观察组在对照组治疗基础上给予益气通脉饮治疗,1个月后比较两组临床的疗效,评估治疗前后中医证候、心绞痛症状分级和血脂水平。临床检测的数据通过统计产品与服务解决方案(Statistical Product and Service Solutions,SPSS) 19.0软件进行分析和处理,计量的数据使用平均数±标准差(x±s)表示,采用双侧t检验,计数的数据采用χ~2检验,以%表示,以P<0.05为差异有统计学意义。结果:治疗后,对照组和观察组都有一定疗效,但观察组的改善中医证候总有效率95.56%(43/45),高于对照组的82.22%(37/45),两组比较具有统计学意义(P<0.05);心绞痛的症状总有效率观察组为93.33%(42/45),对照组为77.78%(35/45),两组比较差异有统计学意义(P<0.05);与治疗前相比较,两组治疗后的三酰甘油(Triglyceride,TG)、血清总胆固醇(Serum Total Cholesterol,TC)、高密度脂蛋白胆固醇(High Density Liptein Cholesterol,HDL-C)水平均降低(P<0.05),且观察组治疗后低于对照组(P<0.05),两组治疗后的HDL-C升高(P<0.05),组间比较,差异无统计学意义(P>0.05)。结论:益气通脉饮治疗气虚血瘀型冠心病心绞痛的疗效显著,值得临床进一步研究与推广应用。

Clinical observation of Yiqi Tongmai Decoction combined with western medicine in treating 90 cases of coronary heart disease angina pectoris with TCM syndromes of Qi deficiency and blood stagnation

Objective:To study the clinical effect of Yiqi Tongmai Decoction(益气通脉饮)in treating coronary heart disease angina pectoris with TCM syndromes of Qi deficiency and blood stagnation.Methods:A total of 90 patients with Qi deficiency and blood stasis type angina pectoris admitted to our hospital from October 2017 to February 2019 were enrolled.All participants will be randomly assigned to two groups:the control group(treated with conventional western medicine)and the observation group(treated with Yiqi Tongmai Decoction on the basis of the treatment of the control group)in a 1:1 ratio.The general data of the two groups were statistically processed,and the difference was not statistically significant(P>0.05),so it was comparable.The TCM syndrome,angina symptom classification and blood lipid level before and after treatment were measured to evaluate the clinical efficacy of the two groups after 1 month.Statistical analysis was performed using software SPSS 19.0.The measured data was expressed as mean±SD(±s)used by the unpaired 2-tailed Student’s t test and the counted data were analyzed byχ~2 test,expressed in%.P<0.05 was accepted as statistically significant.Results:After treatment,both the control group and the observation group had a certain clinical efficacy.Compared with the control group,the observation group displayed an increased total effective rate of TCM symptoms 95.56%(43/45)vs 82.22%(37/45)(P<0.05),an improved total effective rate of angina symptom classification 93.33%(42/45)vs 77.78%(35/45)(P<0.05),and lower TG,TC and LDL-C levels(P<0.05).Moreover,compared with pro-treatment,the levels of HDL-C in the two groups were higher(P<0.05).But there was no significant difference between the two groups(P>0.05).Conclusion:Yiqi Tongmai Decoction is effective in the treatment of angina pectoris with Qi deficiency and blood stasis type,which is worthy of further research and application.