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| Na+／H+交换体阻滞剂对糖尿病鼠心肌细胞缺氧／复氧损伤的保护机制 | |
| 引用本文： | 解 辉,潘晓黎,吴 伟.Na+／H+交换体阻滞剂对糖尿病鼠心肌细胞缺氧／复氧损伤的保护机制[J].大连医科大学学报,2008,30(1):14-17. |
| 作者姓名： | 解 辉 潘晓黎 吴 伟 |
| 作者单位： | 1. 沈阳市红十字会医院,内分泌科,辽宁,沈阳,110013 2. 中国医科大学,附属一院,内分泌科,辽宁,沈阳,110001 3. 中国医科大学,附属一院急诊科,辽宁,沈阳,110001 |
| 摘 要： | 目的]探讨Na /H 交换体阻滞剂对糖尿病鼠心肌细胞缺氧/复氧损伤的保护机制.方法]通过观察糖尿病鼠单个心肌细胞在缺氧/复氧时细胞胞浆Ca2 ＞浓度的动态变化以及Na /H 交换体阻滞剂(EIPA)在不同时相(糖尿病单纯缺氧组即DM组,缺氧/复氧全程给药组即DM-EIPA组,复氧前给药1组即DM-EIPA 1组,复氧前给药2组即DM-EIPA 2组)对Ca2 浓度的影响来研究Na /H 交换体阻滞剂对糖尿病鼠心肌细胞缺氧/复氧损伤的保护机制.结果]DM-EIPA组在180 min的缺氧期间Ca2 浓度的上升幅度显著低于DM组、DM-EIPA 1组和DM-EIPA 2组;在复氧期间DM*EIPA组和DM-EIPA 2组Ca2 浓度的上升幅度显著低于DM组,而前两组之间差异无显著性意义.结论]EIPA可以通过减轻钙超载而对缺血再灌注的糖尿痛鼠心肌细胞起保护作用,可能对糖尿病心肌病的发生发展有预防作用. |
| 关 键 词： | 糖尿病 心肌病变 缺血/再灌注损伤 Na /H 交换体阻滞剂 交换体 阻滞剂 糖尿病鼠 心肌细胞缺氧 复氧损伤 保护机制 cell cardiac muscle mouse retarder discussion mechanism protection 预防作用 发展 发生 心肌病 鼠心肌细胞 糖尿痛 缺血再灌注 |
| 文章编号： | 1671-7295（2008）01-0014-04 |
| 收稿时间： | 2007-06-14 |
| 修稿时间： | 2007-11-10 |
Na~+/H~+ permutoid retarder to diabetic mouse cardiac muscle cell oxyen deficit/reaerationon injury protection mechanism discussion |
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| XIE Hui,PAN Xiao-li and WU Wei.Na~+/H~+ permutoid retarder to diabetic mouse cardiac muscle cell oxyen deficit/reaerationon injury protection mechanism discussion[J].Journal of Dalian Medical University,2008,30(1):14-17. | |
| Authors: | XIE Hui PAN Xiao-li and WU Wei |
| Affiliation: | 1.Department of Endocrinology;Shenyang Red Cross Hospital;Shenyang 110013;China;2.Department of Endocrinology;the First Affiliated Hospital of China Medical University;Shenyang 110001;3.Department of Emergency;China |
| Abstract: | Objective] To detect the protection mechanism of Na+/H+ permutoid retarder to diabetic mouse cardiac muscle cell oxygen deficit/reaeration on injury.Methods] By observing the cytoplasmic Ca2+ concentration change of single cardiocyte in I/R status and the effect of Na+/H+ permutoid retarder to Ca2+ concentration in different phases(diabetes pure oxygen-lack deficit group called DM group,the oxygen deficit/reaeration on entire journey for medicine group called DM-EIPA group,the first group giringmedicine b... |
| Keywords: | diabete cardiomyopathy ischemia/reperfusion injury Na+/H+ exchanger |
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