| 尾加压素Ⅱ生物学效应研究进展 |
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| 引用本文： | 竺晓鸣,杜冠华. 尾加压素Ⅱ生物学效应研究进展[J]. 中国药理学通报, 2006, 22(6): 651-654 |
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| 作者姓名： | 竺晓鸣 杜冠华 |
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| 作者单位： | 中国医学科学院·中国协和医科大学药物研究所国家药物筛选中心,北京,100050 |
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| 摘 要： | 尾加压素Ⅱ最初是从硬骨鱼中发现的环状多肽,是迄今为止发现的收缩血管活性最强的物质。尾加压素Ⅱ及其受体广泛分布于中枢神经系统和心血管系统中,并参与了许多疾病的病理发生过程。尾加压素Ⅱ在体内调节作用非常复杂,目前还缺乏对它全面的了解,大量研究资料表明尾加压素Ⅱ将可能成为很多疾病特别是心血管系统疾病治疗的又一个新靶点。
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| 关 键 词： | 尾加压素Ⅱ 尾加压素Ⅱ受体 收缩血管 心肌重构 |
| 文章编号： | 1001-1978(2006)06-0651-04 |
| 收稿时间： | 2006-02-19 |
| 修稿时间： | 2006-04-05 |
Progress in the study of biological activities of Urotensin Ⅱ |
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| ZHU Xiao-ming,DU Guan-hua. Progress in the study of biological activities of Urotensin Ⅱ[J]. Chinese Pharmacological Bulletin, 2006, 22(6): 651-654 |
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| Authors: | ZHU Xiao-ming DU Guan-hua |
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| Abstract: | Urotensin Ⅱ,a cycle peptide originally found from the fish,is the most potent vasoconstrictor.Urotensin Ⅱand its receptor have been found in central nerve system,cardiovascular system and other organs and tissues.It has been suggested that urotensin Ⅱplays important roles in the physiological and pathological procedures.Based on the evidences obtained from experiments,urotensin Ⅱmay become a new target for treating many diseases,particularly for cardiovascular diseases. |
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| Keywords: | urotensin Ⅱ urotensin Ⅱ receptor vasoconstrictor myocardial remodeling |
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