| 阿维A与氨甲蝶呤治疗重度斑块型银屑病的疗效 |
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| 引用本文： | 刘盼盼,匡叶红,张江林,李捷,粟娟,陈翔,朱武.阿维A与氨甲蝶呤治疗重度斑块型银屑病的疗效[J].中南大学学报(医学版),2016,41(8):804-808. |
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| 作者姓名： | 刘盼盼 匡叶红 张江林 李捷 粟娟 陈翔 朱武 |
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| 作者单位： | 中南大学湘雅医院皮肤科，长沙410008 |
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| 基金项目： | 湖南省财政厅湖南卫生项目(2100201)； 湖南省科技厅科技计划项目(2013FJ6004)。 |
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| 摘 要： | 目的：观察阿维A与氨甲蝶呤治疗重度斑块型银屑病的疗效。方法：54例确诊为斑块型银屑病的患者被分为阿维A组(32例，口服阿维A30 mg，每日1次)和氨甲蝶呤组(22例，口服氨甲蝶呤15 mg，每周1次)，均外用卡泊三醇软膏和硼酸软膏，疗程8周。以银屑病面积和严重度指数(psoriasis area and severity index，PASI)作为观察指标，比较两种药物的疗效。 结果：治疗后，阿维A组和氨甲蝶呤组PASI评分均较治疗前下降(P<0.001)，PASI评分改善率和PASI评分有效率在两组间比较差异均无统计学意义(均P>0.05)。结论：阿维A或氨甲蝶呤治疗重度斑块型银屑病均有效，且疗效相当。
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| 关 键 词： | 阿维A 氨甲蝶呤 银屑病 |
Effect of acitretin and methotrexate on treatment of
severe plaque psoriasis |
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| LIU Panpan,KUANG Yehong,ZHANG Jianglin,LI Jie,SU Juan,CHEN Xiang,ZHU Wu.Effect of acitretin and methotrexate on treatment of
severe plaque psoriasis[J].Journal of Central South University (Medical Sciences)Journal of Central South University (Medical Sciences),2016,41(8):804-808. |
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| Authors: | LIU Panpan KUANG Yehong ZHANG Jianglin LI Jie SU Juan CHEN Xiang ZHU Wu |
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| Affiliation: | Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China |
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| Abstract: | Objective: To evaluate effects of acitretin and methotrexate on treatment of severe plaque psoriasis.
Methods: A total of 54 patients were treated with either acitretin (32 patients; 30 mg per day) or methotrexate (22 patients; 15 mg per week) for 8 weeks. The therapeutic effects of the two drugs were evaluated according to the psoriasis area and severity index (PASI).
Results: After 8 weeks of treatment, the score of PASI decreased in both the acitretin group and the methotrexate group (P<0.001). However, there was no significant differences neither in the percentage reduction in the PASI score nor in PASI response rate between the two groups (P>0.05).
Conclusion: Acitretin and methotrexate exert similar therapeutic effect in severe plaque psoriasis. |
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| Keywords: | acitretin methotrexate psoriasis |
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