| 腺病毒载体介导的大鼠反义血管紧张素Ⅱ受体Ⅰ_B基因转移对大鼠颈动脉损伤后新生内膜增殖的影响 |
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| 引用本文： | 欧阳平,许顶立,黄洪莲,刘伊丽,侯玉清,宋后燕,戴云.腺病毒载体介导的大鼠反义血管紧张素Ⅱ受体Ⅰ_B基因转移对大鼠颈动脉损伤后新生内膜增殖的影响[J].南方医科大学学报,1998(3). |
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| 作者姓名： | 欧阳平 许顶立 黄洪莲 刘伊丽 侯玉清 宋后燕 戴云 |
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| 作者单位： | 南方医院心内科，上海医科大学分子遗传研究室 |
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| 摘 要： | 目的探讨腺病毒载体介导的大鼠反义血管紧张素Ⅱ受体ⅠＢ（ＡＴ１Ｂ）ＲＮＡ转移对大鼠颈动脉损伤后新生内膜的影响。方法利用重组腺病毒载体将大鼠反义ＡＴ１ＢＲＮＡ转移至大鼠颈动脉球囊损伤模型中，２１天后观察其对新生内膜形成的影响。结果用腺病毒载体转导大鼠反义ＡＴ１ＢＲＮＡ至大鼠球囊损伤的颈动脉，２１天后，与对照组相比，损伤血管新生内膜／中层面积比降低了４７％（Ｐ＜０．００１）。结论反义ＡＴ１ＢＲＮＡ对血管成形术后再狭窄可能有一定的预防作用
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| 关 键 词： | 反义AT1_B 腺病毒载体 再狭窄 新生内膜 基因治疗 |
Effects of rat antisense AT1 B gene transfer by adenoviral vector mediated on neointima proliferation after rat carotid artery injury |
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| Ou Yangping ,Xu Dingli ,Huang Honglian ,Liu Yili ,Hou Yuqing ,Song Houyan Dai Yun.Effects of rat antisense AT1 B gene transfer by adenoviral vector mediated on neointima proliferation after rat carotid artery injury[J].Journal of Southern Medical University,1998(3). |
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| Authors: | Ou Yangping Xu Dingli Huang Honglian Liu Yili Hou Yuqing Song Houyan Dai Yun |
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| Affiliation: | Ou Yangping 1,Xu Dingli 1,Huang Honglian 1,Liu Yili 1,Hou Yuqing 1,Song Houyan 2 Dai Yun 1 1 Department of Cardiology,Nanfang Hospital,First Military Medical University,Guangzhou 510515 2 Institute of Molecular Genetics,Shanghai M |
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| Abstract: | |
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| Keywords: | antisense AT1 B adenovirus vector restenosis neointima hyperplasia gene therapy |
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