首页 | 官方网站   微博 | 高级检索  
     


Different Approaches in Therapy Aiming to Stabilize an Unstable Atherosclerotic Plaque
Authors:Michal Kowara  Agnieszka Cudnoch-Jedrzejewska
Affiliation:Laboratory of Centre for Preclinical Research, Department of Experimental and Clinical Physiology, Medical University of Warsaw, 02-091 Warsaw, Poland;
Abstract:Atherosclerotic plaque vulnerability is a vital clinical problem as vulnerable plaques tend to rupture, which results in atherosclerosis complications—myocardial infarctions and subsequent cardiovascular deaths. Therefore, methods aiming to stabilize such plaques are in great demand. In this brief review, the idea of atherosclerotic plaque stabilization and five main approaches—towards the regulation of metabolism, macrophages and cellular death, inflammation, reactive oxygen species, and extracellular matrix remodeling have been presented. Moreover, apart from classical approaches (targeted at the general mechanisms of plaque destabilization), there are also alternative approaches targeted either at certain plaques which have just become vulnerable or targeted at the minimization of the consequences of atherosclerotic plaque erosion or rupture. These alternative approaches have also been briefly mentioned in this review.
Keywords:atherosclerotic plaque   stabilization   vulnerable plaque   inflammation   macrophage   intravascular ultrasound   myocardial infarction   necrotic cores   cell death
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司    京ICP备09084417号-23

京公网安备 11010802026262号