细菌性肝脓肿合并2型糖尿病患者血清炎性因子及外周血T细胞亚群的变化分析

目的探讨2型糖尿病合并细菌性肝脓肿患者血清炎性因子、外周血T淋巴细胞亚群的变化及其意义。方法分析重庆市巴南区人民医院2015年1月至2018年7月收治的细菌性肝脓肿患者112例的病例资料,其中合并2型糖尿病患者41例(糖尿病组),未合并2型糖尿病患者71例(非糖尿病组),比较2组治疗前、治疗后的血清降钙素原(PCT)、C反应蛋白(CRP)、白细胞介素6(IL-6)、外周血中T淋巴细胞亚群(CD3^+、CD4^+、CD8^+T细胞)的水平。结果糖尿病组患者血清PCT、CRP、IL-6水平高于非糖尿病组(均P<0.05),CD3^+、CD4^+T细胞水平及CD4^+/CD8^+值低于非糖尿病组(均P<0.05);CD8^+T细胞水平与非糖尿病组相比,差异无统计学意义(P>0.05)。糖尿病组和非糖尿病组患者在治疗14 d后的血清PCT、CRP、IL-6水平较本组治疗前显著降低(均P<0.05),CD3^+、CD4^+T细胞水平、CD4^+/CD8^+值较本组治疗前显著升高(均P<0.05)。结论与单纯细菌性肝脓肿患者比较,细菌性肝脓肿合并2型糖尿病患者血清PCT、CRP、IL-6水平升高更加显著,免疫功能损害更加严重。

Changes of serum inflammatory factors and peripheral blood T cell subsets in patients with bacterial liver abscess and type 2 diabetes mellitus

Objective To explore the changes and significance of serum inflammatory factors and peripheral blood T lymphocyte subsets in patients with type 2 diabetes mellitus and bacterial liver abscess.Methods A total of 112 patients with bacterial liver abscess in People′s Hospital of Ba′nan District from January 2015 to July 2018 were selected,including 41 cases of type 2 diabetes mellitus(DM group)and 71 cases of unassociated type 2 diabetes mellitus patients(NDM group).Their clinical data were retrospectively analyzed.The serum procalcitonin(PCT),C-reactive protein(CRP)and interleukin-6(IL-6)and peripheral blood T lymphocyte subsets(CD3^+,CD4^+,CD8^+T cells)of patients in the 2 groups were detected and compared before and after treatment.Results The serum levels of PCT,CRP and IL-6 in the DM group were higher than those in the NDM group(P<0.05).The CD3+T cells,CD4^+T cells,CD4^+/CD8^+ratio in the DM group were lower than those in the NDM group(P<0.05).The CD8^+T cells showed no significant differences between the DM group and NDM group(P>0.05).The serum levels of PCT,CRP,IL-6 in the DM group and the NDM group were significantly decreased after treatment(P<0.05),while the CD3+T cells,CD4+T cells and CD4^+/CD8^+ratio were significantly increased compared with those levels before treatment(P<0.05).Conclusion Compared with the patients with bacterial liver abscess,the levels of serum PCT,CRP and IL-6 in patients with type 2 diabetes mellitus complicated with bacterial liver abscess increased more significantly,and the immune function damage was more serious.