| 西托溴铵的合成 |
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| 引用本文： | 柴雨柱,鲁亚洲,朱先锋,陈严波.西托溴铵的合成[J].药学与临床研究,2010,18(1):88-89. |
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| 作者姓名： | 柴雨柱 鲁亚洲 朱先锋 陈严波 |
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| 作者单位： | 江苏济川制药有限公司药物研究院,泰兴,225441 |
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| 摘 要： | 目的：合成西托溴铵并改进合成工艺。方法：以氢溴酸东莨菪碱为起始原料，经中和反应、季铵化反应制得西托溴铵。结果：所得产物经元素分析、紫外光谱、红外光谱、核磁共振谱及质谱等确证了结构。结论：此工艺路线方法简便，原料易得，便于工业化生产。
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| 关 键 词： | 西托溴铵 抗胆碱能 合成 |
| 收稿时间： | 2009/10/24 0:00:00 |
| 修稿时间： | 2009/11/26 0:00:00 |
Synthesis of Cimetropium Bromide |
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| CHAI Yu-zhu,LU Ya-zhou,ZHU Xian-feng and CHEN Yan-bo.Synthesis of Cimetropium Bromide[J].Pharmacertical and Clinical Research,2010,18(1):88-89. |
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| Authors: | CHAI Yu-zhu LU Ya-zhou ZHU Xian-feng and CHEN Yan-bo |
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| Affiliation: | CHAI Yu-zhu,LU Ya-zhou,ZHU Xian-feng,CHEN Yan-bo R&D Institute of Jumpcan Pharmaceutical Co.,Ltd,Taixin 225441,China |
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| Abstract: | Objective:To synthesize cimetropium bromide and optimize the process.Methods:Cimetropium bromide was synthesized by neutralization and quaternization from scopolamine hydrobromide.Results:Chemical structure of cimetropium bromide was confirmed by element analysis,UV,IR,1HNMR,13CNMR and ESI-MS etc.Conclusion :This process can be easily controlled and is suitable for the industrialized scale production. |
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| Keywords: | Cimetropium bromide Anticholinergic Synthesis |
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