老年原发性高血压患者动态脉压与脉搏波传导速度的相关性

目的探讨老年高血压患者动态脉压与脉搏波传导速度的相关性。方法选择原发性高血压患者229例,根据24 h动态血压监测的结果,按照动态脉压值分为动态脉压<60 mmHg组(112例)和动态脉压≥60mmHg组(117例)。2组均行颈桡脉搏波传导速度、血生化检测。结果动态脉压≥60 mmHg组颈-桡动脉脉搏波传导速度显著高于动态脉压<60 mmHg组(11.5±1.4 m/s比10.3±1.2 m/s,P<0.01);颈-桡动脉脉搏波传导速度与年龄、偶测收缩压、空腹血糖、总胆固醇、低密度脂蛋白胆固醇、24 h收缩压、白昼收缩压、夜间收缩压、24 h脉压、白昼脉压、夜间脉压呈正相关(r=0.302,0.248,0.224,0.306,0.365,0.466,0.492,0.372,0.552,0.546,0.488,均P<0.01);多元线性逐步回归分析发现,24 h脉压、24 h收缩压、年龄、低密度脂蛋白胆固醇是影响颈-桡动脉脉搏波传导速度主要危险因素。结论老年高血压患者动态脉压与脉搏波传导速度密切相关。

Association Between Ambulatory Pulse Pressure and Pulse Wave Velocity in Elderly Hypertensive Patients

Aim To investigate the association between ambulatory pulse pressure and carotid-radial pulse wave velocity(crPWV) in elderly patients with essential hypertension.Method According to the results of 24 h ambulatory pulse pressure(APP),229 patients were divided to APP≥60 mmHg group(n=117) and APP<60 mmHg group(n=112),crPWV,blood glucose and lipid profiles were recorded.Results The crPWV of APP≥60 mmHg group was significantly higher than APP<60 mmHg group(11.5±1.4 m/s vs 10.3±1.2 m/s,P<0.01).Pearson relation analysis showed that crPWV level positively correlated with age,systolic blood pressure(SBP),fasting blood glucose(FBG),total cholesterol(TC),low density lipoprotein cholesterol(LDLC),24hSBP,dSBP,nSBP,24hPP,dPP,nPP(r=0.302,0.248,0.224,0.306,0.365,0.466,0.492,0.372,0.552,0.546,0.488,all P<0.01).Multiple linear regression showed that 24hPP were significant and independent factor for crPWV in elderly patients with essential hypertension.Conclusion The study showed that 24hPP was closely related with atherosclerosis in elderly patients with essential hypertension.