成都地区肺炎链球菌对抗菌药物的耐药性调查

目的 了解成都地区临床分离的肺炎链球菌的耐药性，为肺炎链球菌感染临床合理应用抗菌药物提供理论依据。方法 二倍琼脂稀释法测定11种抗菌药物对肺炎链球菌的最低抑菌浓度(MIC)。结果 91．94％菌株对青霉素敏感，8．06％中度耐药；88．71％菌株对SMZ／TMP敏感，11．29％中度耐药；肺炎链球菌对头孢呋辛、头孢噻肟、头孢毗肟、氧氟沙星、司帕沙星、美洛培南、万古霉素敏感率为100％；对红霉素、克林霉素耐药率相当高，分别达到62．90％和74．19％。结论 成都地区肺炎链球菌对青霉素耐药率较低，而对大环内酯类和克林霉素类耐药率较高。

Survey on antibiotic-resistance of Streptococcus pneumoniae in Chengdu area

Objective To survey the antibiotics resistance of Streptococcus pneumoniae in Chengdu China and guide the appropriate antibiotics against Streptococcus peneumoniae infection. Methods Minimal inhibitory concentrations (MICs) of Streptococcus pneumoniae to 10 antibiotics were measured using two-fold agar dilution method. Results A toal of 91.94% Streptococcus pneumoniae strains were susceptible to penicillin and 8.06% were moderate activie to it. No strain was resistant to penicillin. The susceptible rate of SMZ/TMP was 88.71% and 11.29% of strains were intermediate. A total of 100% Streptococcus pneumoniae strains were susceptible to cefuroxime, cefotaxime, cefepime, ofloxacin, sparfloxacin, meropenem and vancomycin. The resistant rates of erythromycin and clindamycin were up to 62.90% and 74.19% respectively. Conclusion Streptococcus pneumoniae were rather susceptive to penicillin and the resistant rate of erythromycin and clindamycin were very high.