| 鼎力健胶囊的安全性试验 |
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| 引用本文： | 项华,查捷,章晓玲,孙建荣,俞国强. 鼎力健胶囊的安全性试验[J]. 癌变．畸变．突变, 2007, 19(3): 253-255. DOI: 10.3969/j.issn.1004-616X.2007.03.024 |
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| 作者姓名： | 项华 查捷 章晓玲 孙建荣 俞国强 |
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| 作者单位： | 杭州市疾病预防控制中心,浙江,杭州,310006 |
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| 摘 要： | 背景与目的:鼎力健胶囊是由蚂蚁粉与中药组成的复方制剂,为确定其对人体健康是否会造成损害,对其进行食品安全性毒理学评价.材料与方法:用急性毒性试验、小鼠骨髓细胞微核试验、小鼠精子畸形试验和Ames试验方法对鼎力健胶囊的急性毒性和遗传毒性进行研究.结果:急性毒性试验大鼠、小鼠最大耐受剂量(maximum tolerated-dose,MTD)均＞20.0 g/kg体重,属无毒级物质;Ames试验、小鼠骨髓细胞微核试验和小鼠睾丸精子畸形试验结果均为阴性.结论:鼎力健胶囊无急性毒性和致突变性.
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| 关 键 词： | 鼎力健胶囊 急性毒性 微核试验 精子畸形 Ames试验 |
| 文章编号： | 1004-616X（2007）03-0253-03 |
| 收稿时间： | 2006-03-22 |
| 修稿时间： | 2006-03-222006-08-22 |
Toxicity Study on DingLiJian Capsule |
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| XIANG Hua,ZHA Jie,ZHANG Xiao-ling,SUN Jian-rong,YU Guo-qiang. Toxicity Study on DingLiJian Capsule[J]. Carcinogenesis,Teratogenesis and Mutagenesis, 2007, 19(3): 253-255. DOI: 10.3969/j.issn.1004-616X.2007.03.024 |
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| Authors: | XIANG Hua ZHA Jie ZHANG Xiao-ling SUN Jian-rong YU Guo-qiang |
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| Affiliation: | Hangzhou Center for Disease Control and Prevention, Hangzhou 310006, Zhejiang, China |
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| Abstract: | BACKGROUND & AIM:DingLiJian capsule is a constituent of herbal medicine composed of ant powder compounded preparation.It was necessary to make toxicological assessment of DingLiJian capsule.MATERIALS AND METHODS:The acute toxicity in mice and rat,micronuclei test of bone marrow cell in mice,sperm shape abnormality test in mice and Ames test were used.RESULTS:The maximum tolerated dose(MTD)of rats and mice was more than 20.0 g/kg,so the DingLiJian capsule belonged to non-toxic substance;the results of micronucleus test of bone marrow cell,sperm shape abnormallty test in mice and Ames test were negative.CONCLUSION:The DingLiJian capsule has no acute toxicity and abnormality. |
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| Keywords: | DingLiJian capsule acute toxicity micronucleus test sperm shape abnormality Ames test |
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