宫颈癌复发及预后临床因素分析

目的探讨宫颈癌患者的临床因素与其复发及预后的关系。方法回顾分析我院收治的80例宫颈癌患者的临床资料，采用Kaplan—Meier法计算总生存率，Log—rank法检验和单因素预后分析，采用Logistic回归分析临床因素与复发间的相关性，并运用COX回归分析临床因素与预后间的相关性。结果患者的FIGO分期、病理分化程度、组织学类型、术后辅助放化疗以及淋巴结转移是影响复发的相关因素（P〈0．05）。Logistic多因素分析结果显示：FIGO分期、病理分化程度、组织学类型、淋巴结转移以及术后辅助放化疗是影响复发的独立因素。患者的发病年龄、FIGO分期、肿瘤直径、病理分化程度、肌层浸润深度、组织学类型、术后辅助放化疗以及淋巴结转移是影响预后的相关因素（P〈0．05）。COX回归多因素分析结果显示：年龄、FIGO分期，病理分化程度、肌层浸润深度、组织学类型、淋巴结转移以及术后辅助放化疗是影响预后的独立因素。结论临床分期晚、低分化、非鳞癌以及淋巴转移是影响宫颈癌的预后和复发的主要危险因素，发病年龄、肿瘤直径以及肌层浸润深度为影响宫颈癌预后的一个重要因素，其治疗也值得进一步探讨。

ANALYSIS OF THE CLINICAL FACTORS RELEVANT TO RECCURENCE AND PROGNOSIS OF CERVICAL CANCER

Objective To study the relationship between clinical features of patients with cervical cancer reccurence and prognostic. Methods The clinical data of 80 cervical cancer patients were retrospectively analyzed. The total survival rate were calculated by Kaplan - Meier method and Logrank test, and the prognosis of single factor were analyzed. And the correlation between clinical factor and prognosis were analyzed by COX regression, the corre- lation between clinical factor and recurrence were analyzed by Logistic regression. Results Univariate analysis showed that ： clinical stage, tumor diameter, tumor differentiation, muscular infiltration depth, tissue histological type, lymph node metastasis and adjuvant chemotherapy were recurrent factors （p 〈 0. 05 ）. Multivariate analysis of recurrence showed that： FIGO stage, histological differentiation, lymph node metastasis, adjuvant radiotherapy and chemo- therapy are independent recurrent factors. Univariate analysis showed that： age, clinical stage, tumor diameter, tumor differentiation, muscular infiltration depth, tissue histological type, lymph node metastasis and adjuvant chemotherapy were prognostic factors （p 〈 O. 05 ）. Multivariate analysis showed that ： FIGO stage, histological differentiation, lymph node metastasis, adjuvant radiotherapy and chemotherapy are independent prognostic factors. Conclusion FI- GO stage,histological differentiation, non squamous cell carcinomas and lymph node metastasis are independent prognostic and recurrent factors. Age, diameter of tumor and muscular infiltration depth may be an important factor to influence the prognosis of cervical cancer and its treatment is worthy of further discussion.