生长抑素联合清胰汤治疗重症胰腺炎的临床研究

目的比较生长抑素和生长抑素早期联合应用清胰汤治疗重症急性胰腺炎的疗效。方法回顾性对比分析过去三年间本科收治的43例重症急性胰腺炎患者,其中生长抑素组(对照组)20例,生长抑素 清胰汤组(治疗组)23例。比较两组多项实验室指标、病情程度、脏器功能衰竭发生率、局部并发症发牛率和病死率等指标。结果治疗组腹部症状体征恢复时间、血淀粉酶、C反应蛋白(CRP)、乳酸脱氢酶(LDH)、门冬氨酸氨基转移酶(AST)、急性生理和慢性健康状况评分(APACHEⅡ)等的恢复优于对照组(P<0.05)。治疗组局部并发症和脏器衰竭发生率低于对照组,但差异无显著性。两组病死率差异无显著性。结论生长抑素联合清胰汤与生长抑素单独应用相比,明显改善重症急性胰腺炎病情,提高治疗效果。

Treatment of severe acute pancreatitis by combination of somatostatin and Qingyitang

Aim To study the efficacy of combination of somatostatin and Qingyitang (formulation of Chinese traditional medicine) in the treatment of severe acute pancreatitis (SAP). Methods The retrospective study was based on 43 patients with SAP who hospitalized in our department during the past three years , in which 23 cases in treatment group were given the combination of somatostatin and Qingyitang, and the other 20 cases were given only somatostatin as control. Several SAP indices were reviewed, including abdominal symptoms, biochemical markers, disease severity assessment, and rates of organ failure, local complication and mortality. Results In treatment group, the abdominal symptoms and APACHEII scores were significantly improved, and the SAP indices, such as the levels of serum amylase, C-reactive protein (CRP), LDH, and AST were normalized in shorter times when compared to those of control group (P < 0.05). The rates of local complication and organ failure occurrence in treatment group were lower than those in control group, but there was no significant difference. The rates of mortality in two groups were similar. Conclusion Combination of som-tostatin and Qingyitang is a recommended recipe for treatment of SAP.