脓毒症患者血清IL-6与脑损伤的相关性分析

目的探讨脓毒症患者血清白细胞介素-6(IL -6)水平与中枢神经损伤的关系。方法选择符合脓毒症诊断标准同时无中枢
神经系统疾病的患者22例作为研究对象，检测血清IL-6和神经元特异性烯醇化酶（NSE）水平，并根据IL-6的水平分为低中高3
个浓度组，比较3个浓度组NSE水平及急性生理和慢性健康（APACHEII）评分的差异，分析血清IL-6与NSE及APACHEII的
相关性。结果IL-6低中高3个浓度组NSE水平具有显著性差异（P<0.001），浓度分别为(10.29±4.05)、(16.06±5.84)、(23.97±
3.28)μg/L。IL-6三个浓度组的APACHEII评分同样具有显著性差异（P=0.009），分值分别为14.17±4.67、16.40±4.84和24.00±
6.26。相关性分析显示IL-6与NSE和APACHEII评分均具有显著的正相关性，相关系数分别为r=0.788(P<0.001)和0.733(P<
0.001)。结论脓毒症患者血清IL-6的浓度同患者危重程度和中枢神经损伤均有显著地相关性，可以作为动态监测脓毒性脑损
伤的标志物。

Correlation analysis between serum interleukin-6 and central nervous injury in septic patients

Objective To explore the relationship between interleukin-6(IL-6) production and central nervous injury in septic patients.Methods Twenty-two septic patients without central nervous system diseases were examined for serum IL-6 and neuron-specific enolase(NSE) levels,and the serum NSE levels and APACHEII scores were compared between patients with low,moderate,and high serum IL-6 levels.The correlations between NSE,APACHEII and serum IL-6 were analyzed.Results In patients with low,moderate,and high serum IL-6 levels,the serum levels of NSE were 10.29±4.05,16.06±5.84 and 23.97±3.28 μg/L,respectively,showing a significant difference between the 3 groups(P<0.001).The APACHEII scores also differed significantly between the 3 groups(14.17±4.67,16.40±4.84,and 24.00±6.26,respectively,P=0.009).Correlation analysis showed significant positive correlations of IL-6 with NSE(r=0.788,P<0.001) and with APACHEII scores(r=0.733,P<0.001).Conclusion In septic patients,serum IL-6 level is significantly correlated with the severity of sepsis and brain injury,and can be used as a marker to monitor brain injury in septic patients.