| 雌激素对大鼠肝再生过程中肝细胞超微结构的影响 |
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| 引用本文： | 胡宗义,武忠弼.雌激素对大鼠肝再生过程中肝细胞超微结构的影响[J].华中科技大学学报(医学版),1990(5). |
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| 作者姓名： | 胡宗义 武忠弼 |
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| 作者单位： | 同济医科大学实验医学研究中心超微病理研究室
(胡宗义)，同济医科大学实验医学研究中心超微病理研究室(武忠弼) |
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| 摘 要： | 本文采用形态测量技术,分析了雌激素对大鼠肝再生过程中肝细胞超微结构的影响。结果显示,使用雌激素的大鼠肝细胞核及核仁体积明显高于对照组,以术后1～3d最明显(P<0.001);同时,线粒体数密度也明显增加,术后1、3、7d与对照组比较差异有极显著性意义(P<0.01),表明雌激素具有促进肝再生过程中肝细胞线粒体增生的作用。作者认为,雌激素的上述作用是雌激索促进肝细胞再生的形态学表现。
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| 关 键 词： | 肝再生 显微镜检查 电子 形态测量 雌激素类 |
The Effect of Estrogen on the Ultrastructure of Rat Hepatocytes During Liver Regeneration |
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| Hu Zongyi,Wu Zhongbi.The Effect of Estrogen on the Ultrastructure of Rat Hepatocytes During Liver Regeneration[J].Journal of Huazhong University of Science and Technology(Health Sciences),1990(5). |
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| Authors: | Hu Zongyi Wu Zhongbi |
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| Affiliation: | Hu Zongyi,Wu ZhongbiDepartment of Ultrastructural Pathology,Tongji Medical University,Wuhan |
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| Abstract: | In the present study,morphometric techniques were used to analyze the effect of estrogen on the ultrastructure of rat hepatocytes during liver regeneration The results revealed that the volume of the nuclei and nucleoli ofhepatocytes was significantly greater in estrogen-treated rats than in control groups,especially so 1-3 days postoperatively (P<0.001).The numerical density of mitochondria also increased prominently,with statistically significant difference on days 1,3,7 after operation (P<0.01),indicating that estrogen could promote the proliferation of mitochondria of hepatocytes during liver regeneration.From the foregoing it may be suggested that the above effects of estrogen are actually the morphological evidence to justify the promoting role of estrogen in hepa-tocyte regeneration. |
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| Keywords: | liver regeneration microscopy electron morphometry estrogens |
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