| 三七总皂苷对老年性痴呆大鼠空间探索学习记忆力的影响 |
| |
| 引用本文： | 钟振国,屈泽强,鲍运平,王乃平,张凤芬,张雯艳.三七总皂苷对老年性痴呆大鼠空间探索学习记忆力的影响[J].北京中医药大学学报,2006,29(1):34-37. |
| |
| 作者姓名： | 钟振国 屈泽强 鲍运平 王乃平 张凤芬 张雯艳 |
| |
| 作者单位： | 广西中医学院,广西,530001;广西中医学院,广西,530001;广西中医学院,广西,530001;广西中医学院,广西,530001;广西中医学院,广西,530001;广西中医学院,广西,530001 |
| |
| 基金项目： | 广西科技厅科研项目
,
广西人事厅资助项目
,
广西教育厅科研项目 |
| |
| 摘 要： | 目的探讨三七总皂苷(PNS)对老年性痴呆(AD)模型大鼠空间学习记忆功能障碍的改善作用.方法以D-半乳糖腹腔注射致亚急性损伤合并鹅膏蕈氨酸损毁双侧大脑Meynert基底核建立AD大鼠动物模型;Morris水迷宫进行学习记忆能力检测.结果PNS高、低剂量组大鼠在Morris水迷宫测试中,逃避潜伏期明显缩短,寻求次数、原平台象限比、跨越原平台次数明显增加,与模型组比较有显著意义(P<0.05).结论PNS对AD模型大鼠空间学习记忆损害具有明显改善作用.
|
| 关 键 词： | 三七总皂苷 老年性痴呆 动物模型 Morris水迷宫 学习与记忆 大鼠 |
| 修稿时间： | 2004年11月9日 |
Influence of PNS on abilities of space search, learning and memory in rats with Alzheimer's disease |
| |
| ZHONG Zhen-guo,QU Ze-qiang,BAO Yun-ping,WANG Nai-ping,ZHANG Feng-fen,ZHANG Wen-yan.Influence of PNS on abilities of space search, learning and memory in rats with Alzheimer's disease[J].Journal of Beijing University of Traditional Chinese Medicine,2006,29(1):34-37. |
| |
| Authors: | ZHONG Zhen-guo QU Ze-qiang BAO Yun-ping WANG Nai-ping ZHANG Feng-fen ZHANG Wen-yan |
| |
| Abstract: | Objective To investigate the relieving effect of panax notoginsenoside(PNS) on the disorder of the abilities of space search,learning and memory in rat model of Alzheimer's disease(AD).Methods The AD rat model was established by intraperitoneal injection of D-galactose resulting in subacute lesion combined with ibotenic acid injection resulting in destroy of bilateral basal nuclei of Meynert.The test of Morris water maze(MWM) was used to examine the changes of the abilities of space search,learning and memory in rats.Result All of the test indexes in MWM showed that the abilities of space search,learning and memory in different groups with different PNS doses remarkably improved compared with that of the model group(P<0.05). Conclusion PNS has a significant relieving effect on the lesion of the abilities of space search,learning and memory in AD model rats. |
| |
| Keywords: | panax notoginsenoside Alzheimer's disease animal model Morris water maze learning and memory rats |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
