| HSP70基因多态性对煤工尘肺遗传易感性的影响 |
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| 引用本文： | 周舫,秦卫东,王玉珍,李伟辉,梁守沛,姚武,吴逸明.HSP70基因多态性对煤工尘肺遗传易感性的影响[J].卫生研究,2010,39(3). |
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| 作者姓名： | 周舫 秦卫东 王玉珍 李伟辉 梁守沛 姚武 吴逸明 |
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| 作者单位： | 郑州大学公共卫生学院劳动卫生学教研室,郑州,450001 |
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| 基金项目： | 国家自然科学基金资助项目(No.30600490,30571552); 河南省教育厅科技创新人才支持计划(No.2008HASTIT028); 河南省教育厅自然科学研究资助项目(No.2008A320018) |
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| 摘 要： | 目的探讨职业人群中HSP70基因对煤工尘肺遗传易感性的影响。方法随机选取河南省某煤矿的工人200例,其中100例胸片结果判定为0+的为病例组,100例胸片结果判定为正常的为对照组。采用PCR-RFLP方法检测两组观察对象中HSP70的基因型分布情况。结果病例组HSP70-1b2/b2基因型的频率明显高于对照组(χ2=8.26,P0.05),b2/b2基因型个体发生煤工尘肺的风险是b1/b1基因型个体的2.36倍(OR=2.36,95%CI=1.61～3.30);而HSP70-2和HSP70-hom的多态性在两组间差异无显著性。结论HSP70-1b2/b2基因型可能是煤工尘肺的一个易感基因型,存在该基因型的机体可能更容易罹患煤工尘肺。
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| 关 键 词： | 热休克蛋白70 基因多态性 煤工尘肺 |
Effect of HSP70 gene polymorphism on genetic susceptibility of pneumoconiosis of coal worker |
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| ZHOU Fang,QIN Weidong,WANG Yuzhen,LI Weihui,LIANG Shoupei,YAO Wu,WU Yiming.Effect of HSP70 gene polymorphism on genetic susceptibility of pneumoconiosis of coal worker[J].Journal of Hygiene Research,2010,39(3). |
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| Authors: | ZHOU Fang QIN Weidong WANG Yuzhen LI Weihui LIANG Shoupei YAO Wu WU Yiming |
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| Affiliation: | ZHOU Fang,QIN Weidong,WANG Yuzhen,LI Weihui,LIANG Shoupei,YAO Wu,WU Yiming Department of Occupational Health,College of Public Health,Zhengzhou University,Zhengzhou 450001,China |
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| Abstract: | Objective To explore the effect of heat shock protein 70(HSP70) gene polymorphism on genetic susceptibility of pneumoconiosis of coal worker(CWP).Methods 100 workers whose sternites were assessed 0 + were chosen as the case group and 100 workers as the control.HSP70 genotypes were analyzed by the polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) technique.Results There were significantly differences in HSP70-1 b2 /b2 genotype(χ2 = 8.26,P < 0.05) between the case group and the control,the risks of CWP in the individuals with b2 /b2 genotype were 2.36 times than those with b1 /b1 genotype.The polymorphism of HSP70-2 and HSP70-hom had no statistics significance in the difference of the two groups.Conclusion The results suggested that the individual with HSP70-1 b2 /b2 genotype may be a predisposing genotype to CWP and the individuals with the genotype could have weaker adaptability than the others. |
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| Keywords: | heat shock protein 70 gene polymorphism pneumoconiosis of coal worker |
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