女性尖锐湿疣患者宫颈亚临床感染与复发关系的研究

目的探讨女性尖锐湿疣(CA)患者宫颈中人乳头瘤病毒(HPV)亚临床感染与CA复发的关系.方法根据临床及病理结果,收集107例女性CA患者及65例正常女性患者的宫颈拭子,将其分为高复发组(52例)、低复发组(55例)和正常对照组(65例),利用基因芯片技术检测患者宫颈中是否存在HPV病毒及其亚型,并进行统计学分析.结果高复发组中67.3%(35/52)例检测出HPV病毒,低复发组中34.5%(19/55)检测出HPV病毒,正常对照组4.6%(3/65)检测出HPV病毒,各组间差异有统计学意义.结论女性CA患者宫颈中存在HPV病毒感染的潜在病灶可能是CA复发的原因之一.

Relationship between subclinical cervical human papillomavirus (HPV) infection and recurrence of condyloma acuminatum in patients

Objective To investigate the relationship between subclinical cervical HPV infection and recurrence of condyloma acuminatum (CA) in patients. Methods Cervical swabs were collected from 52 patients with frequently recurrent CA, 55 patients with infrequently recurrent CA, and 65 normal human controls. The Cenechip method was performed to detect the presence and type of HPV in cervical swabs followed by a statistical analysis. Results HPV was found in 67.3% (35/52) of swabs from patients with frequently recurrent CA, 5% (19/55) from patients with infrequently recurrent CA, and 4.6% (3/65) in the controls. There was a statistical difference among the three groups in the detection rate of HPV. Conclusion The subclinical cervical HPV infection may contribute to the recurrence of CA.