藤梨根化学成分和抗肿瘤药理作用研究进展

对猕猴桃科猕猴桃属中药藤梨根化学成分、抗肿瘤方面药理作用进行文献整理及分析,为下一步开展的藤梨根药效物质基础研究提供科学依据和理论基础。查阅近30年国内外公开发表的文献,对藤梨根中的多种化学成分、藤梨根的抗肿瘤药理作用进行综述。结果显示藤梨根化学成分复杂,至今已从藤梨根中分离并鉴定了90余种化学成分,共分为6大类,分别为五环三萜类化合物38个,黄酮类化合物16个,蒽醌类化合物6个,甾体类化合物5个,生物碱类化合物5个和其他类化合物25个;在抗肿瘤药理活性研究方面,其在抗胃癌,食管癌,结肠癌,肺癌等方面均显示了较好的活性。目前对藤梨根的化学成分和抗肿瘤药理作用方面取得了一定的进展,尤其在抗肿瘤方面的作用受到医学界的广泛关注,但是缺少对其水提取物中有效成分的深入研究。对藤梨根的进一步研究将有利于开发新的药物和充分利用天然药物资源。

Advances on Chemical Constituents and Antitumor Effects of the Root of Actinidia chinensis

To analyze the chemical constituents and antitumor effects of the root of Actinidia chinensis, in order to provide scientific and theoretical basis for investigating its pharmacodynamic substances. The chemical constituents and antitumor effects were reviewed from related domestic and abroad published literatures in the past 30 years. The chemical constituents of the root of A. chinensis are complex. There are about 90 chemical constituents isolated and identified up to now, including 38 pentacyclic triterpenes, 16 flavonoids, 6 anthraquinones, 5 steroids, 5 alkaloids and 25 other type of compounds. It has significant antitumor activities on gastric cancer, esophageal cancer, colon cancer and lung cancer. Herein, we obtained some progress on its chemical constituents and pharmacological activities, especially its antitumor effects. However, limited research has focused on its aqueous extract. Further research is helpful for the development of new medicines and making the most use of plant resources.