C-myc与PCNA在肺癌组织中的表达及其意义

目的：探讨C-myc和PCNA（增殖细胞核抗原）在肺癌和正常肺组织或肺大疱组织中的表达及其与肺癌发生发展的关系。方法：应用免疫组化方法测定50例原发性肺癌（鳞癌24例,腺癌19例,腺鳞癌4例,小细胞肺癌3例）和16例正常肺组织及肺大疱组织中C-myc及PCNA的表达。结果：50例原发性肺癌组织中C-myc、PCNA的阳性表达率分别为66%（33/50）、74%（37/50）,正常组织中两种抗体均无阳性表达,肺癌组织中C-myc和PCNA的阳性表达率明显高于对照组肺组织,C-myc在3例小细胞肺癌中无表达。结论：C-myc与PCNA在肺癌组织中的表达无相关性;C-myc和PCNA表达增加在肺癌早期即可发生,与肺癌分期无相关性,可能与肺癌的发生发展有关,对肺癌的早期诊断和分子靶向治疗有帮助。

C-myc and PCNA expression in lung cancer and its significance

Objective：To investigate the expression of C-myc and PCNA（proliferating cell nuclear antigen） in lung cancer and normal lung tissue or lung tissue of bullae and the relationship to the development of lung cancer.Methods： Immunohistochemical staining was used to measure expression of C-myc and PCNA in 50 patients with primary lung cancer（squamous cell carcinoma in 24 cases,19 cases of adenocarcinoma,adenosquamous carcinoma in 4 cases,3 cases of small cell lung cancer） and 16 normal lung tissues or lung bullae tissue.Results： The expression of C-myc,PCNA positive rates were 66%（33/50）,74%（37/50） in total of 50 cases of primary lung cancer,no expression of two antibodies observed in normal tissue.The expression of C-myc and PCNA positive rate was significantly higher in lung cancer than lung tissue,and there was no expression of C-myc in 3 cases of small cell lung cancer.Conclusion： C-myc expression in lung cancer was no correlation to PCNA;increased expression of C-myc and PCNA which was developed in the early stage in lung cancer had no association with the staging of lung cancer;they may be related to the development of lung cancer and are helpful to the early diagnosis and molecular targeting therapy.