| 舒林酸对卵巢癌细胞系CP70顺铂耐药性的逆转作用 |
| |
| 引用本文： | 邵娟,辛晓燕,魏燕,段海霞.舒林酸对卵巢癌细胞系CP70顺铂耐药性的逆转作用[J].陕西肿瘤医学,2011(2):208-211. |
| |
| 作者姓名： | 邵娟 辛晓燕 魏燕 段海霞 |
| |
| 作者单位： | 第四军医大学西京医院妇产科,陕西西安710032 |
| |
| 摘 要： | 目的：研究舒林酸体外逆转卵巢癌细胞系CP70的顺铂耐药性，并探讨其与β—catenin表达的关系。方法：MTT法检测单独使用舒林酸或顺铂及两药联合使用时对CP70细胞的抑制作用，免疫细胞化学和Westernblot方法检测细胞内β—catenin表达水平。结果：两药联合处理细胞后顺铂耐药逆转倍数为6．01，联合处理组的细胞中β—catenin表达明显降低。结论：舒林酸能部分逆转CP70细胞对顺铂的耐药性，且此作用可能与下调细胞的β—catenin表达有关。
|
| 关 键 词： | 舒林酸 卵巢癌 顺铂 耐药性 |
Sulindac resensitizes cisplatin -resistant human ovarian cancer cells CP70 |
| |
| Affiliation: | SHAO Juan, XIN Xiao - yan, WEI Yan, DUAN Hai - xia (Oepartment of Obstetrics and Gynecology, Xijing Hospital, Fourth Military Medical University, Xi＇an 710032, China.) |
| |
| Abstract: | Objective：To study the effect of sulindac in resensitizing cisplatin - resistant human ovarian cancer cells CP70, and to discuss the related mechanism. Methods： MTF assay was used to assess the inhibitory effects of sulindae, cisplatin alone or a combination of both on CP70 cells. Immunohistochemical analysis and Western blotting were employed to observe the expression of β - catenin in different groups. Results： The resensitizing fold of cisplatin combined with sulindac was 6.01. The expression of β - catenin had the most prominent decrease in CP70 cells in the combination group. Conclusion： Sulindac can partially resensitize cisplatin -resistant CP70 cells,which might be related to the down - regulation of β- catenin. |
| |
| Keywords: | sulindac ovarian cancer cisplatin drug resistance |
| 本文献已被 维普 等数据库收录！ |
|
