| 血清胱抑素C与肌酐在肾功能不同损害期患者中的应用比较 |
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| 引用本文： | 姚虹,苏建荣,李岩.血清胱抑素C与肌酐在肾功能不同损害期患者中的应用比较[J].中国实验诊断学,2007,11(3):332-334. |
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| 作者姓名： | 姚虹 苏建荣 李岩 |
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| 作者单位： | 首都医科大学附属北京友谊医院,临床检验中心,北京,100050 |
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| 摘 要： | 目的研究肾功能不同损害期患者血清胱抑素C（Scc）浓度变化及其与血清肌酐（Scr）和肌酐清除率（Ccr）的相关性，并对血清肌酐和胱抑素C在反映肾小球滤过率（GFR）中的应用作一比较。方法采用免疫比浊法测定125例患者SCC水平；采用Jaffe法测定SCr和Ccr，并进行相关分析。结果See与Scr呈高度正相关（r=0．783，P〈0．01），See与Cer呈高度负相关（r=-0．835，P〈0．01）；同时在肾功能损伤早期，See比Scr和Ccr更敏感，而且See与Ccr的相关性（r=-0．835）要好于Scr和Ccr的相关性（r=-0．615），两者有显著性差异（P〈0．05）。结论See是反映GFR的一项敏感指标。可以取代Sex和Ccr在临床上常规应用。
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| 关 键 词： | Scc Scr Ccr GFR |
| 文章编号： | 1007-4287（2007）03-0332-03 |
| 收稿时间： | 2006-03-11 |
| 修稿时间： | 2006年3月11日 |
Comparison the usefulness of serum cystain C and serum creatinine in the detection of renal dysfunction |
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| YAO Hong,SU Jian-rong,LI Yan.Comparison the usefulness of serum cystain C and serum creatinine in the detection of renal dysfunction[J].Chinese Journal of Laboratory Diagnosis,2007,11(3):332-334. |
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| Authors: | YAO Hong SU Jian-rong LI Yan |
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| Abstract: | Objective To detect the Scc.Scr and Ccr in 125 patients with renal dysfunction and make correlation? between Scc and Scr.Ccr,then evaluate the usefulness of Scc and Scr in the detection of GFR.Methods To determine the Scc.Scr and Ccr in 125 patients.Results Significant positive correlation was observed between Scc and Scr(r=0.783,P<0.01);significant negative correlation was observed between Scc and Ccr(r=-0.835,P<0.01).In the mild renal dysfunction,Scr is more sensitive than Scr and Ccr.The correlation between Scc and Ccr(r=-0.835) is better than that between Scr and Ccr(r=-0.615) with statistical difference(P<0.05).Conclusion Scc can subtitute Scr and Ccr,and may be clinically utilized as a sensitive indicator of GFR. |
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| Keywords: | Scc Scr Ccr GFR |
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