| 玉泉丸对大鼠肝细胞色素P450酶活性的影响 |
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| 引用本文： | 水彦芳,高燕,魏玉辉,李波霞,段好刚,秦红岩,张冬梅,武新安. 玉泉丸对大鼠肝细胞色素P450酶活性的影响[J]. 兰州大学学报(医学版), 2009, 35(1): 58-60 |
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| 作者姓名： | 水彦芳 高燕 魏玉辉 李波霞 段好刚 秦红岩 张冬梅 武新安 |
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| 作者单位： | 兰州大学第一医院药剂科,甘肃,兰州,730000;金川公司职工医院药剂科,甘肃,兰州,737100 |
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| 基金项目： | 甘肃省中医药管理局基金 |
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| 摘 要： | 目的考察玉泉丸对大鼠肝细胞色素P450酶活性的影响。方法大鼠分别给予生理盐水、西咪替丁、苯巴比妥钠和玉泉丸灌胃7d后，腹腔注射非那西丁，不同时间点采集血样，用HPLC法测定血浆中探针药物非那西丁的浓度，用DAS软件估算其药代动力学参数。结果生理盐水组、西咪替丁组、苯巴比妥钠组和玉泉丸组探针药物≠1／2分别为（93．51±9．21）、（161．67±10．95）、（85．36±8．98）和（31．12±7．09）min。结论玉泉丸对大鼠肝细胞色素P450酶活性有一定的诱导作用。
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| 关 键 词： | 玉泉丸 细胞色素P450酶 非那西丁 |
Effects of Yuquan pill on liver cytochrome P450 in rats |
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| SHUI Yan-fang,GAO Yan,WEI Yu-hui,LI Bo-xia,DUAN Hao-gang,QIN Hong-yan,ZHANG Dong-mei,Wu Xin-an. Effects of Yuquan pill on liver cytochrome P450 in rats[J]. Journal of Lanzhou University (Medical Sciences), 2009, 35(1): 58-60 |
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| Authors: | SHUI Yan-fang GAO Yan WEI Yu-hui LI Bo-xia DUAN Hao-gang QIN Hong-yan ZHANG Dong-mei Wu Xin-an |
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| Affiliation: | SHUI Yan-fang, GAO Yan, WEI Yu-hui, LI Bo-xia, DUAN Hao-gang, QIN Hong-yan, ZHANG Dong-mei, Wu Xin-an (1. Department of Pharmacy, First Hospital of Lanzhou University, Lanzhou 730000, China; 2. Department of Pharmacy, Hospital of Jinchuan Group LTD, Jinchang, 737100, Gansu, China) |
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| Abstract: | Objective To investigate the effects of Yuquan pill on liver cytochrome P450 （CYP450） in rats. Methods After orally administrating normal saline, cimetidine, phenobarbital sodium and Yuquan pill for 7 d, phenacetin （as a probe drug） was given to all rats by intra-peritoneal injection. The blood samples were collected at different time. ＆ developed HPLC method was used to determine the concentrations of the probe drug in rat plasma, and pharmacokinetic parameters were estimated by DAS software. Results The t1/2 values of probe drug in groups of normal saline, cimetidine, phenobarbital sodium and Yuquan pill were （93.51±9.21）, （161.67±10.95）, （85.36±8.98） and （31.12±7.09） rain, respectively. Conclusion Yuquan pill has inductive effects on rat liver CYP450. |
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| Keywords: | Yuquan pill cytochrome P450 phenacetin |
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