| PTEN与信号转导及肿瘤 |
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| 引用本文： | 孙艳花,钟雪云.PTEN与信号转导及肿瘤[J].中国病理生理杂志,2002,18(3):326-329. |
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| 作者姓名： | 孙艳花 钟雪云 |
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| 作者单位： | 暨南大学医学院病理教研室，广东 广州 510632 |
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| 摘 要： | ＴＥＮ1] (ｐｈｏｓｐｈａｔａｓｅａｎｄｔｅｎｓｉｎｈｏｍｏｌｏｇｙｄｅｌｅｔｅｄｏｎｃｈｒｏｍｏｓｏｍｅｔｅｎ)又名ＭＭＡＣ1 2 ] (ｍｕｔａｔｅｄｉｎｍｕｔｉｐｌｙａｄａｎｃｅｄｃａｎｃｅｒ 1 )和ＴＥＰ1 3 ] (ＴＧＦ -βｒｅｇｕｌａｔｅｄａｎｄｅｐｉｔｈｅｌｉａｌｃｅｌｌ -ｒｉｃｈｅｄｐｈｏｓｐｈａｔａｓｅ 1 ) (以下均称为ＰＴＥＮ) ,是 1 997年由 3个研究小组先后发现的一个具有双特异磷酸酶活性的抑癌基因。ＰＴＥＮ基因异常广泛存在于人类多种恶性肿瘤 ,如恶性神经胶质瘤、前列腺癌、子宫内膜癌、黑色素瘤等…
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| 关 键 词： | PTEN 磷酸酶类 信号转导 肿瘤 |
| 文章编号： | 1000-4718(2002)03-0326-04 |
| 收稿时间： | 2001-10-24 |
| 修稿时间： | 2001年10月24 |
PTEN and signal transduction and tumor |
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| SUN Yan-hua,ZHONG Xue-yun.PTEN and signal transduction and tumor[J].Chinese Journal of Pathophysiology,2002,18(3):326-329. |
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| Authors: | SUN Yan-hua ZHONG Xue-yun |
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| Affiliation: | Department of Pathology, Medical College of Jinan University, Guangzhou 510632, China |
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| Abstract: | PTEN is a candidate tumor suppressor which has sequence homology with dual-specificity phosphatase. PTEN is a multifunctional protein endowed with a phosphatase activity capable of dephosphorylating both tyrosine phosphate, serine/threonine phosphate residues on proteins and phospholipids of the phosphatidylinositol pathway. PTEN appears to be mutated at considerable frequency in several types of human tumors, including those from brain, breast, endometrium, and prostate. PTEN play an important role in pathogenesis of tumor, tumor cell invasion and metastasis. In this review, we will discuss the chemical structure of PTEN, its phosphatase activity, the ability of affecting signal transduction, and its mutational status in cancer. |
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| Keywords: | PTEN Phosphatases Signal transduction Neoplasms |
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