| 调节内质网应激反应抑制肿瘤细胞自噬的研究进展 |
| |
| 引用本文： | 田浩,韩卓越,代景友,张新晨.调节内质网应激反应抑制肿瘤细胞自噬的研究进展[J].中国普外基础与临床杂志,2012,19(4):452-455. |
| |
| 作者姓名： | 田浩 韩卓越 代景友 张新晨 |
| |
| 作者单位： | 哈尔滨医科大学第二附属医院普外六肝胆外科 黑龙江哈尔滨 150000 |
| |
| 摘 要： | 目的了解调节内质网应激反应抑制肿瘤细胞自噬的研究进展。方法对国内外有关内质网应激反应抑制肿瘤细胞自噬的文献进行综述。结果在Ca2+释放及未折叠蛋白聚集而诱发的内质网应激反应中,自噬可被多种通路激活,并调节生理及病理过程。结论在肿瘤细胞内质网应激反应中,调节其反应通路因子进而抑制自噬的发生仍需进一步研究。
|
| 关 键 词： | 自噬 内质网应激反应 未折叠蛋白反应 钙离子 |
Research Progress of Regulating The Endoplasmic Reticulum Stress Response to Inhibit Autophagy in Tumor Cells |
| |
| TIAN Hao
,
HAN Zhuo-yue
,
DAI Jing-you
,
ZHANG Xin-chen.Research Progress of Regulating The Endoplasmic Reticulum Stress Response to Inhibit Autophagy in Tumor Cells[J].Chinese Journal of Bases and Clinics In General Surgery,2012,19(4):452-455. |
| |
| Authors: | TIAN Hao HAN Zhuo-yue DAI Jing-you ZHANG Xin-chen |
| |
| Affiliation: | . Department of Hepatobiliary Surgery and General Surgery,The Second Affiliated Hospital of Harbin Medical University,Harbin 150000,Heilongjiang Province,China |
| |
| Abstract: | Objective To realize the research progress of regulating the endoplasmic reticulum stress response to inhibit autophagy in tumor cells.Method The literatures about regulating the endoplasmic reticulum stress response to inhibit autophagy in tumor cells were reviewed.Result In the endoplasmic reticulum stress response induced by the release of calcium and accumulation of unfolded proteins,autophagy can be activated by several pathways,and to regulate physiological and pathological processes.Conclusion Further research about the endoplasmic reticulum stress response in tumor cells need to be done to regulate the response factors to inhibit autophagy. |
| |
| Keywords: | Autophagy Endoplasmic reticulum stress response Unfolded protein response Calcium |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
