| 4-溴-5-硝基-1H-吡咯-2-甲酸乙酯合成方法改进 |
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| 引用本文： | 石磊,柴文,席海涛,孙小强,袁荣鑫. 4-溴-5-硝基-1H-吡咯-2-甲酸乙酯合成方法改进[J]. 江苏石油化工学院学报, 2011, 0(3): 13-16 |
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| 作者姓名： | 石磊 柴文 席海涛 孙小强 袁荣鑫 |
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| 作者单位： | [1]常州大学石油化工学院,江苏常州213164 [2]常熟理工学院,江苏常熟215500 |
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| 摘 要： | 以吡咯为原料经酰基化、NBS为溴化、乙醇钠亲核取代、发烟硝酸硝化,以64.3%的总收率合成目标化合物4-溴-5-硝基-1H-吡咯-2-甲酸乙酯,合成工艺适合工业化生产,目标化合物的结构经1 H NMR、MS等表征。
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| 关 键 词： | 吡咯 溴化 4-溴-5-硝基-1H-吡咯-2-甲酸乙酯 |
Improvement in the Syntheic Method of 4-Bromo-5-Nitro-1H-Pyrrole-2-Carboxylic Acid Ethyl Ester |
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| SHI Lei,CHAI Wen,XI Hai-tao,SUN Xiao-qiang,YUAN Rong-xin. Improvement in the Syntheic Method of 4-Bromo-5-Nitro-1H-Pyrrole-2-Carboxylic Acid Ethyl Ester[J]. Journal of Jiangsu Institute of Petrochemical Technology, 2011, 0(3): 13-16 |
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| Authors: | SHI Lei CHAI Wen XI Hai-tao SUN Xiao-qiang YUAN Rong-xin |
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| Affiliation: | 1.School of Petrochemical Engineering,Changzhou University,Changzhou 213164,China;2.Changshu Institute of Technologhy,Changshu 215500,China) |
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| Abstract: | Using the pyrrole as the starting material,ethyl 4-bromo-5-nitro-1H-pyrrole-2-carboxylate was synthesized through acylation,bromation by NBS,nucleophilic substitution by NaOC2H5 and nitration by fuming nitric acid.The total yield of the target product was 64.3 %,and the synthetic technique is suitable for industrial production.The target product structure was characterized by 1H NMR,MS spectra,etc. |
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| Keywords: | pyrrole bromation ethyl 4-bromo-5-nitro-1H-pyrrole-2-carboxylate |
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