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| 原发性高血压胰岛素抵抗与肾素-血管紧张素系统的关联 | |
| 引用本文： | 王慧,闫朝丽,胡康洪.原发性高血压胰岛素抵抗与肾素-血管紧张素系统的关联[J].内蒙古医学院学报,2011,33(1):80-84. |
| 作者姓名： | 王慧 闫朝丽 胡康洪 |
| 作者单位： | 1. 内蒙古医学院,内蒙古呼和浩特,010059 2. 内蒙古医学院附属医院内分泌科 3. 德国雷根斯堡大学分子和细胞解剖学研究所 |
| 摘 要： | 近年来,在原发性高血压病人和部分高血压动物模型中发现胰岛素抵抗的存在。在原发性高血压的发生发展中,肾素-血管紧张素系统中的血管紧张素II可促进胰岛素抵抗,涉及到PI3K通路,作用于胰岛素下游通路的Akt和Glut4,进而影响了葡萄糖的利用,导致了胰岛素抵抗。本文从基础及临床两方面,阐明ARB与ACEI改善高血压胰岛素抵抗的可能机制,为临床开展ARB与ACEI改善胰岛素抵抗提供依据。 |
| 关 键 词： | 原发性高血压 胰岛素抵抗 RAS系统 PI3K |
THE RELATIONSHIP BETWEEN INSULIN RESISTANCE OF ESSENTIAL HYPERTENSION AND RENIN - ANGIOTENSIN - SYSTEM |
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| WANG Hui,YAN Zhao - li,HU Kang - hong.THE RELATIONSHIP BETWEEN INSULIN RESISTANCE OF ESSENTIAL HYPERTENSION AND RENIN - ANGIOTENSIN - SYSTEM[J].Acta Academiae Medicinae Neimongol,2011,33(1):80-84. | |
| Authors: | WANG Hui YAN Zhao - li HU Kang - hong |
| Affiliation: | WANG Hui,YAN Zhao-li,HU Kang-hong(Inner Monogolia Medical College,Hohhot 010059 China) |
| Abstract: | Recently,Insulin resistance is found in essential hypertension patients and parts of hypertensive animal models.During the course of primary hypertension development,angiotensin II promotes insulin resistance,involving the approach of PI3K which plays an important role in the Akt and Glut4 of insulin downstream pathway,influences the application of glucose and results in insulin resistance.This paper demonstrate the possible mechanism of ARB and ACEI of improving insulin resistance of hypertension patients ... |
| Keywords: | PI3K |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |
