Prevalence of second generation antibody to hepatitis C virus among voluntary blood donors in Osaka,Japan |
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Authors: | Drs Hideo Tanaka Drs Tomohiko Hiyama Drs Hideaki Tsukuma Drs Yasuto Okubo Drs Hajime Yamano Drs Akira Kitada Drs Isaburo Fujimoto |
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Affiliation: | (1) Department of Field Research, Center for Adult Diseases, Osaka, 1-3-3 Nakamichi, Higashinari-ku, 573 Osaka, Japan;(2) Osaka Red Cross Blood Center, Osaka, Japan |
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Abstract: | To clarify the demographic characteristics of the prevalence of hepatitis C virus (HCV) infection in Osaka, Japan, where hepatocellular carcinoma is common, we investigated the screening data of antibody to HCV (anti-HCV, DAINABOTHCVPHA, second generation assay) in 197,600 voluntary blood donors residing in Osaka. The study found that age-standardized prevalence of anti-HCV was significantly higher than that of HBsAg (2.25cf 0.86 percent among males,P<0.001; 2.17cf 0.55 percent among females,P<0.001. It was much higher in the blood donors aged 55–64 years than in those aged 16–54 years (8.49cf 1.32 percent among males,P<10–5; 7.26cf 1.42 percent among females,P<10–5). The prevalence of anti-HCV among males was significantly higher than that of females in the younger (25–34 years) generations (1.02 to 1.49 percentcf 0.71 to 1.13 percent,P<0.05). A similar tendency was observed in the prevalence of high-titer (212) anti-HCV. The number of coinfection (both HBsAg and anti-HCV seropositive) was very small, and it was not statistically different from the expected number. |
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Keywords: | Blood donors hepatitis B virus hepatitis C virus hepatocellular carcinoma Japan |
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