抵御新发、突发病毒性传染病的新思路——天然免疫机制的系统医学研究和针对宿主的广谱抗病毒药物的研发

病毒性传染疾病是人类社会的重大威胁,严重危害人民生命安全和国家、社会安定.随着国内外经济发展,城镇化、都市化、全球化的进程加快,新发和突发病毒性传染病呈现不断增高的趋势,如艾滋病病毒、严重急性呼吸综合征病毒、禽流感病毒、甲流感病毒、埃博拉病毒等近年来一次又一次在世界不同地区频繁发生并蔓延、流行.本次埃博拉病毒在西非的爆发和疫情失控更再次警示我国和国际社会关于发展有效防治新发、突发病毒性传染病措施的重要性和紧迫性.天然免疫与宿主抗病研究领域的突破性进展为解决该世界性难题开辟了新的思路和途径.

New Strategies to Fight Against Emerging Viral Infectious Diseases—Systems Medicine for Innate Defense and Development of Broad-Spectrum Antiviral Therapeutics Targeting Host Factors

Viral diseases are big threats to human beings, jeopardizing people''s safety, national security and social stability. Due to rapid economic development, urbanization and globalization, emergent and new emerging viral infectious diseases have shown an alarming increasing trend. Diseases caused by a number of different viruses, such as human immune deficient virus-1, severe acute respiratory syndrome virus, avian influenza virus and Ebola virus, rapidly spread in various parts of the world and occur more and more frequently. The current Ebola outbreak in West Africa and its grievous epidemic situation again warns China and the international community of a pressing need to develop effective measures to combat emergent and new emerging viral diseases. The breakthroughs in the field of innate immunity and host defense now provide us new avenues to solve this global problem.