奥曲肽联合大黄治疗急性胰腺炎的疗效研究

目的探讨奥曲肽联合大黄治疗急性胰腺炎的疗效，旨在为临床治疗提供有利的参考依据。方法选取2008年6月～2012年6月在我院内科住院治疗的急性胰腺炎患者共62例，均经病史、心电图、24h动态心电图、心脏彩超等检查确诊，按照随机、对照的原则将选取的上述62例受试对象分为观察组（奥曲肽联合大黄治疗）32例和对照组（奥曲肽治疗）30例。比较两组的治疗效果及临床症状改善情况及两组的并发症发生率。结果观察组32例患者应用奥曲肽联合大黄治疗一个疗程后的总有效率90．62％（29／32），对照组30例患者仅应用奥曲肽治疗一个疗程后的总有效率70．00％（9／30），两组的临床疗效比较存在显著性差异，观察组的疗效明显优于对照组（P〈0．05）。两组的显效率、有效率组间比较差异均不显著（P〉0．05）。观察组32例患者应用奥曲肽联合大黄治疗中的腹痛缓解时间明显短于对照组，腹胀消失时间也明显短于对照组，实验室检查结果显示：观察组的血尿淀粉酶恢复时间均较对照组快，两组比较存在显著性差异（P〈0．05）。观察组32例患者无一例出现休克、肾衰，其并发症发生率合计达12．5％，明显低于对照组的并发症发生率（30．0％），两组比较存在显著性差异（P〈0．05）。结论奥曲肽联合大黄治疗急性胰腺炎可以提高单独应用奥曲肽治疗的临床疗效，明显改善患者的临床症状，降低并发症的发生率，具有较好的临床效果，值得广泛推广和应用。

The efficacy of octreotide joint rhubarb in treatment of acute pancreatitis

Objective To investigate the efficacy of octreotide joint rhubarb in treatment of acute pancreatitis, designed to provide a favorable reference for clinical treatment. Methods June 2008 to June 2012 in my hospital inpatient treat- ment of acute pancreatitis in patients with a total of 62 cases were confirmed by medical history, electrocardiogram, 24-hour Hoher heart color ultrasound diagnosed, in accordance with the principles of a randomized, controlled, select- ed the 62 Example subjects divided into two groups （of octreotide joint rhubarb treatment） 32 patients in the control group （octreotide treatment） of 30 cases. Compared between the two groups of treatment and clinical improvement of symptoms, and the complication rate of the two groups. Results Thirty-two patients of the treatment group octreotide combined rhubarb treatment a course after the total efficiency of 90.62% （29/32）, 30 patients of the control group only octreotide treatment of a course after the total efficiency of 70.00%（9/30）. The clinical efficacy comparison there weve significant differences in the efficacy of the treatment group than the control group （P 〈0.05）. The remarkable efficiency of the two groups, the the efficiency group compared the differences there were not significant （P 〉 0.05）. Treatment group 32 cases of abdominal pain relief in patients with octreotide combined with rhubarb treatment time was significantly shorter than the control group, the bloating disappeared time was significantly shorter than the control group, the labo- ratory findings： the urine amylase treatment group recovery time than those in the control group. The two groups there was a significant difference （P 〈 0.05）. The treatment group of 32 patients, no case of shock, renal failure, its total com- plication rate of 12.5%, and the incidence of complications was significantly lower than the control group （30.0%）, the two groups there was a significant difference （P 〈 0.05）. Conclusion Octreotide combined with rhubarb treatment of acute pancreatitis can improve the clinical efficacy of octreotide treatment alone, significantly improve the patient＇s clinical symptoms, reduce the incidence of complications with a better clinical effect, should be popularized and applied.