针刺治疗化疗相关周围神经病变的系统评价和Meta分析

目的系统评价针刺治疗化疗相关周围神经病变的临床疗效。方法计算机检索中国知网、万方数据库、维普数据库、PubMed、Cochrane Library中英文数据库,检索时间均从建库至2020年4月20日。由2名独立研究者独立完成文献筛选、资料提取、偏倚风险评价后,采用RevMan5.3和Stata15.0软件进行Meta分析。结果纳入18项研究,共包括904例患者,其中试验组453例,对照组451例。Meta分析结果显示,针刺能改善患者腓总神经的运动神经传导速度SMD=0.58,95%CI(0.13,1.03)]及感觉神经传导速度SMD=0.40,95%CI(0.18,0.61)],并改善癌痛的疼痛数字评分法(NRS)评分SMD=﹣1.36,95%CI(﹣1.96,﹣0.76)],但两组患者正中神经传导速度的差异无统计学意义(P>0.05)。结论本研究结果表明针刺能有效改善患者腓总神经传导速度,并缓解疼痛症状。但本研究结论仍需更多大样本、高质量的随机对照试验来进一步验证。

Efficacy of Acupuncture for Chemotherapy-induced Peripheral Neuropathy:a Systematic Review and Meta-analysis

Objective To evaluate the efficacy of acupuncture for the treatment of chemotherapy-induced peripheral neuropathy(CIPN).Method The databases of CNKI,Wanfang Data,VIP,PubMed and Cochrane Library were searched up to April 20,2020.Meta-analysis was performed using RevMan 5.3 and Stata 15.0 software after two independent researchers independently completed literature screening,data extraction and risk assessment for bias.Result A total of 904 patients were enrolled in 18 studies,including 453 in the experimental group and 451 in the control group.Meta-analysis results showed that acupuncture could improve motor nerve conduction velocitySMD=0.58,95%CI(0.13,1.03)]and sensory nerve conduction velocitySMD=0.40,95%CI(0.18,0.61)]of the common peroneal nerve,and could improve NRS scoreSMD=-1.36,95%CI(-1.96,-0.76)],but there was no significant difference in median nerve conduction velocity between the two groups(P>0.05).Conclusion The present study indicated that acupuncture could effectively improve the common peroneal nerve conduction velocity and relieve pain symptoms.However,the conclusion still needs to be verified by large-sample and high-quality randomized controlled trials.