针刺配合耳穴贴压对习惯性便秘患者大便性状及肠道菌群的影响

目的 观察针刺配合耳穴贴压对习惯性便秘患者大便性状及肠道菌群的影响.方法 将120例习惯性便秘患者随机分为对照A组、对照B组、研究组,每组40例.3组均给予常规西药治疗,对照A组给予耳穴贴压治疗,对照B组给予针刺治疗,研究组给予针刺治疗配合耳穴贴压,连续治疗2个疗程.观察3组临床疗效、不良反应,对比治疗前后中医证候积分...

Effects of Acupuncture Combined with Auricular Point Sticking on Stool Form and Intestinal Flora in Patients with Habitual Constipation

Objective To observe the effects of acupuncture plus auricular point sticking on stool form and intestinal flora in patients with habitual constipation(HC).Method A total of 120 HC patients were randomized into control group A,control group B and a research group,with 40 cases in each group.Conventional medication was prescribed in all three groups.In addition,control group A was given auricular point sticking,control group B was given acupuncture,and the research group was given auricular point sticking and acupuncture,all for two consecutive treatment courses.The clinical efficacy and adverse reactions were observed in the three groups.The traditional Chinese medicine(TCM)symptoms score(stool form,defecation interval and difficulty defecating),intestinal neurotransmitters[vasoactive intestinal peptide(VIP),nitric oxide(NO)and substance P(SP)],and intestinal flora were compared before and after treatment.Result The total effective rate was higher in the research group than in control groups A and B(P<0.05).After treatment,the scores of stool form,defecation interval and difficulty defecating were lower in the research group than control groups A and B(P<0.05),and were lower in control group B than in control group A(P<0.05).After intervention,the level of serum SP was higher and the levels of NO and VIP were lower in the research group than in control groups A and B(P<0.05),and the level of SP was higher and the levels of NO and VIP were lower in control group B than in control group A(P<0.05).After intervention,the levels of enterobacteriaceae and saccharomycetaceae were lower and the level of lactobacillus was higher in the research group than in control groups A and B(P<0.05),and the levels of enterobacteriaceae and saccharomycetaceae were lower and the level of lactobacillus was higher in control group B than in control group A(P<0.05).There were no significant between-group differences in the adverse reactions including needle fainting,red auricle skin and adhesive tape allergy among the three groups(P>0.05).Conclusion Acupuncture combined with auricular point sticking can help regulate the intestinal flora and neurotransmitters,improve stool form and enhance clinical efficacy in treating HC patients,with high safety evaluation.