血管紧张素转换酶基因多态性与相关疾病关系的研究

血管紧张素转换酶(ACE)是肾素-血管紧张素系统中的关键酶。近年来的研究发现,ACE不同基因型与心脑血管疾病、血管性痴呆等有关。考虑与ACE基因对血管紧张素Ⅱ形成和缓激肽的灭活产生作用,继而影响机体内钠水平代谢、醛固酮的分泌、血管收缩和血管平滑肌细胞增殖,导致血压容易造成遗传性的病理生理改变有关。就近年来国内外有关ACE及其基因多态性与相关疾病的研究结果予以综述。

Research of Relationship Between ACE Gene Polymorphism and Related Disease

Angiotensin-converting enzyme(ACE)is a key enzyme of the renin-angiotensin system.Recent researches showed that,different genotype of ACE has relation to cerebrovascular disease,vascular dementia etc.Considering the ACE gene DD have an effect on the Ang II formed and bradykinin deactivated,thereby affecting the level of the body sodium metabolism and aldosterone secretion,vascular contraction and vascular smooth muscle cell proliferation,caused the pathophysiology change of blood pressure.This article revie...