Synthesis and antimicrobial activity of new 1-[(tetrazol-5-yl)methyl] indole derivatives,their 1,2,4-triazole thioglycosides and acyclic analogs |
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Authors: | Weal A El-Sayed Randa E Abdel Megeid Hebat-Allah S Abbas |
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Affiliation: | (1) Department of Photochemistry, National Research Centre, Cairo, Egypt;(2) Faculty of Specific Education, Ain Shams University, Abbassia, Cairo, Egypt;(3) Department of Chemistry, Faculty of Science, Menoufia University, Shebin El-Koam, Egypt |
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Abstract: | New 1-(tetrazol-5-yl)methyl]indole derivatives, their acyclic nucleoside analogs and the corresponding glycoside derivatives
were synthesized. Furthermore, the )(1,2,4-triazol-3-yl)methyl])-2H-tetrazole derivative as well as the corresponding thioglucoside were prepared. The synthesized compounds were tested for
their antimicrobial activity against Aspergillus Niger, Penicillium sp, Candida albican, Bacillus subtilis, Streptococcus lacti, Escherichia coli, Pseudomonas
sp., and streptomyces sp. Compounds 3, 5 and 19b exhibited potent antibacterial activity and compounds 4, 5 and 10 exhibited high activities against the tested fungi compared with fusidic acid. |
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