基因mRNA表达水平在晚期胃癌化疗敏感性预测中的应用

目的探索切除修复交叉互补基因1（ERCC1）、胸苷酸合成酶（TS）、β-微管蛋白和尿苷二磷酸葡萄糖醛酸转移酶IA1（UGT1A1）检测的对于胃癌化疗敏感性的关系。方法将120例进展期或术后复发的胃癌患者随机分为2组，对照组采用FOI，FOX4方案、FOLFIRI方案或者DCF方案，试验组进行基因mRNA表达水平检测，外根据检测结果针对性地选择上述3种方案。观察2组患者的近期疗效和生活质量。结果2组患者均接受2个周期以上的化疗。试验组有效率及生活质量改善率均显著高于对照组（P〈005）。结论ERCC1、TS、β-微管蛋白和UGT1A1的表达水甲对于晚期胃癌化疗敏感性的预测有着重要的意义，值得临床进一步研究。

Application of mRNA expression in predicting the sensitivity of chemotherapy in gastric cancer patients

Objective To investigate the relationship between the mRNA expression of ER- CC1, TS, β tubulin, UGT1A1 and the sensitivity of chemotherapy in gastric cancer patients. Methods A total of 120 gastric cancer patients were randomly divided into two groups. The control group received FOLFOX4, FOLFIRI or DCF. The mRNA expressions of the patients of experi- ment group were detected at first. Then the above chemotherapy regimen was administered accord- ing to the detection results. The response rate and quality of life of the two groups was observed re- spectively. Results The response rate and the improvement rate of quality of life in the experiment group were higher than those in the control group （P 〈 0.05）. Conclusion The mRNA expression of ERCC1, TS, β- tubulin, UGT1A1 is sensitive in the treatment of gastric cancer patients.