网络药理学的研究方法与应用进展

网络药理学是近年来研究较热的一门新兴的药理学分支学科。以其"多基因,多靶点"的特点与复杂疾病的治疗理念相吻合。区别于传统繁复的药理学实验方法,网络药理学以其独特的研究方法获取药物与靶点相关的信息,既节省时间又节省费用。该文通过检索中国知网和PubMed数据库,从网络构建、网络分析、实验验证3个方面介绍了网络药理学的研究方法,并阐述其应用进展,为深入研究药理学领域拓展新的思路。

Research methods and applications in network pharmacology

Recently, network pharmacology was a pop emerging pharmacology branch. The theory of "multi-gene, multi-target" about network pharmacology was consistent with treatment of complex disease. Different from the traditional experimental methods about pharmacology, the research methods of network pharmacology uniquely obtain the information of drugs and relative targets with less time and less money. In this paper, according to the searching of China Knowledge Resource Integrated Database and PubMed, three aspects about research methods of network pharmacology together with its applications were introduced: network construction, network analysis and experimental validation. The introductions of the methods gave us a new vision in researching the field of pharmacology deeply.