| 香兰素法合成3,4,5-三甲氧基苯甲醛工艺研究 |
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| 引用本文： | 曲小姝,王亚红,祝波.香兰素法合成3,4,5-三甲氧基苯甲醛工艺研究[J].吉林化工学院学报,2006,23(2):3-6. |
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| 作者姓名： | 曲小姝 王亚红 祝波 |
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| 作者单位： | 吉林化工学院,制药与应用化学系,吉林,吉林,132022 |
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| 摘 要： | 采用香兰素法合成药物中间体3,4,5-三甲氧基苯甲醛,总收率为71%.以香兰素为原料,采用溴素为溴代试剂制备5-溴香兰素,收率达96%以上.甲氧基化反应以氯化亚铜作为催化剂,DMF为溶剂,甲醇钠为甲氧基化试剂制得丁香醛,收率为90%.以碳酸二甲酯为甲基化试剂使丁香醛发生甲基化反应制得3,4,5-三甲氧基苯甲醛,收率为82%.
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| 关 键 词： | 3 4 5-三甲氧基苯甲醛 合成 甲基化 甲氧基化 |
| 文章编号： | 1007-2853（2006）02-0003-04 |
| 收稿时间： | 2006-02-17 |
| 修稿时间： | 2006年2月17日 |
Research on synthetic technology of 3,4,5-trimethoxybenzaldehyde from vanillin |
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| QU Xiao-shu,WANG Ya-hong,ZHU Bo.Research on synthetic technology of 3,4,5-trimethoxybenzaldehyde from vanillin[J].Journal of Jilin Institute of Chemical Technology,2006,23(2):3-6. |
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| Authors: | QU Xiao-shu WANG Ya-hong ZHU Bo |
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| Affiliation: | Dept. of Pharmacy and Applied Chemistry, Jilin Institute of Chemical Technology, Jilin City 132022, China |
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| Abstract: | 3,4,5-trimethoxybenzaldehyde is synthesized in 71% yield by vanillin method.5-bromovanillin is afforded in 96% yield by the bromination of vanillin with bromine as brominating agents.Treatment of 5-bromovanillin in DMF with sodium methoxide in the presence of cuprous chloride as catalyst gives syringaldehyde in 90% yield,from which 3,4,5-trimethoxybenzaldehyde is obtained by methylation with dimethylcarbonate in 82% yield. |
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| Keywords: | 3 4 5-trimethoxybenzaldehyde synthesis methylation methoxylation |
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