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| 血清PDGF-BB作为糖尿病视网膜病变生物标志物的研究 | |
| 引用本文： | 陈冉,王应利,周玉梅,陶俊,靳扬扬. 血清PDGF-BB作为糖尿病视网膜病变生物标志物的研究[J]. 国际眼科杂志, 2019, 19(5): 853-856 |
| 作者姓名： | 陈冉 王应利 周玉梅 陶俊 靳扬扬 |
| 作者单位： | 中国河北省唐山市,华北理工大学临床医学院; 中国北京市,应急总医院眼科,中国北京市,应急总医院眼科,中国北京市,应急总医院眼科,中国北京市,应急总医院眼科,中国北京市,应急总医院眼科 |
| 摘 要： | 目的：研究血清中血小板源性生长因子-BB(PDGF-BB)的水平与2型糖尿病患者DR的相关性。 方法：以健康体检者为对照组(75例)，糖尿病病例组分为NDR 25例、NPDR 25例和PDR 25例。用ELISA测定各组样本血清中PDGF-BB水平，并分析血清PDGF-BB与糖尿病病程、HbA1c等各项生化指标的关系，分析PDGF-BB与黄斑厚度的关系。 结果：对照组、NDR组、NPDR组、PDR组血清PDGF-BB水平各组间均有差异(F=14.259，P<0.01)。NPDR组、PDR组血清PDGF-BB水平(535.67±69.21、551.60±103.46pg/mL)均高于对照组、NDR组(400.28±44.55、409.65±50.37pg/mL)。多元回归分析血清PDGF-BB水平与空腹血糖(FPG)、甘油三酯(TG)、糖尿病病程有相关性(均P<0.05)。PDR组血清PDGF-BB水平与黄斑厚度存在相关性(r=0.613，P<0.05)，对照组、NDR组、NPDR组血清PDGF-BB水平与黄斑厚度无相关性(r=0.013、0.051、0.062，均P>0.05)。 结论：血清PDGF-BB水平随着DR病变程度加重而升高，与黄斑水肿存在相关性，并与FPG、TG、糖尿病病程有相关性，可以考虑作为DR的生物学标志物。 |
| 关 键 词： | 糖尿病视网膜病变 血小板源性生长因子-BB 黄斑厚度 |
| 收稿时间： | 2019-02-25 |
| 修稿时间： | 2019-03-28 |
Study on serum PDGF-BB as biomarker for diabetic retinopathy |
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| Ran Chen,Ying-Li Wang,Yu-Mei Zhou,Jun Tao and Yang-Yang Jin. Study on serum PDGF-BB as biomarker for diabetic retinopathy[J]. International Eye Science, 2019, 19(5): 853-856 | |
| Authors: | Ran Chen Ying-Li Wang Yu-Mei Zhou Jun Tao Yang-Yang Jin |
| Affiliation: | College of Graduated School, North China University of Science and Technology, Tangshan 063009, Hebei Province, China; Department of Ophthalmology, China Emergency General Hospital, Beijing 100028, China,Department of Ophthalmology, China Emergency General Hospital, Beijing 100028, China,Department of Ophthalmology, China Emergency General Hospital, Beijing 100028, China,Department of Ophthalmology, China Emergency General Hospital, Beijing 100028, China and Department of Ophthalmology, China Emergency General Hospital, Beijing 100028, China |
| Abstract: | AIM:To observe the correlation between serum level of platelet derived growth factor -BB(PDGF-BB)and diabetic retinopathy(DR)in type 2 diabetic patients. METHODS: Seventy-five cases of healthy subjects underwent physical examination were taken as control group. Diabetic patients were divided into non-diabetic retinopathy group(NDR, 25 cases), non-proliferative diabetic retinopathy group(NPDR, 25 cases)and proliferative diabetic retinopathy group(PDR, 25 cases). Serum level of each group was measured using Enzyme-Linked Immunosorbent Assay(ELISA). Correlation between serum PDGF-BB level and stages of diabetes mellitus, macular thickness, glycosylated hemoglobin, and other biochemical indexes in serum were analyzed. RESULTS: Serum level of PDGF-BB in control group(400.28±44.55pg/mL), NDR(409.65±50.37pg/mL), NPDR(535.67±69.21pg/mL)and PDR subgroup(551.60±103.46pg/mL)were significantly different(F=14.259, P<0.01). Serum level of PDGF-BB in NPDR group and PDR group were higher compared to control group and NDR subgroup. Multiple regression analysis showed that serum level of PDGF-BB positively correlated with fasting blood glucose(FBG), triglycerides(TG)and stages of diabetes(P<0.05). Serum level of PDGF-BB in PDR subgroup correlated with the thickness of macular(r=0.613, P<0.05). Whereas, this correlation was not observed in other groups(rC=0.013, rNDR=0.051, rNPDR=0.062; P>0.05). CONCLUSION: Serum PDGF-BB level was observed to rise with severity of DR and relevant to macula edema. It was also positively correlated to FPG, TG and stages of diabetes. PDGF-BB could be recommended as diagnostic biomarker for DR. |
| Keywords: | diabetic retinopathy platelet-derived growth factor-BB macular thickness |
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